Research workbench
Crystal structure of the human KLHL11-CUL3 complex at 3.1A resolution
Analyse Crystal structure of the human KLHL11-CUL3 complex at 3.1A resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4APF
- Type
- protein
- Length
- 605 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kelch-like protein 11; Cullin 3
- UniProt
- Q9NVR0, Q13618
- Pockets
- 4 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kelch-like protein 11 | protein | 264 | 63% helix, 4% strand | Q9NVR0 |
| B | Cullin 3 | protein | 341 | 81% helix, 0% strand | Q13618 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.41 | 0.81 | 18 | empty |
| 2 | 115 | 0.37 | 0.74 | 27 | empty |
| 3 | 86 | 0.33 | 0.74 | 18 | empty |
| 4 | 54 | 0.32 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1063 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4APF · Crystal structure of the human KLHL11-Cul3 complex at 3.1A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q13618 · AlphaFold monomer V2.0 prediction for cullin-3 (Q13618) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q9NVR0 · AlphaFold monomer V2.0 prediction for kelch-like protein 11 (Q9NVR0) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NVR0
- Every structure of UniProt Q13618
- Elsewhere: RCSB PDB 4APF · PDBe 4APF · UniProt Q9NVR0 · UniProt Q13618
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