Research workbench
Human muscle fructose 1,6-bisphosphate aldolase complexed with fructose 1,6-bisphosphate
Analyse Human muscle fructose 1,6-bisphosphate aldolase complexed with fructose… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ALD
- Type
- protein
- Length
- 363 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-bisphosphate aldolase
- EC
- 4.1.2.13
- UniProt
- P04075
- Ligands
- 2FP
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructose-bisphosphate aldolase (EC 4.1.2.13) | protein | 363 | 44% helix, 15% strand | P04075 |
Ligands and binding sites
- 2FP · 1,6-fructose diphosphate (linear form) · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 573 | 0.77 | 0.84 | 47 | 2FP |
| 2 | 126 | 0.49 | 0.80 | 22 | empty |
| 3 | 59 | 0.34 | 0.78 | 16 | empty |
Compared structures
- 4ALD · Human muscle fructose 1,6-bisphosphate aldolase complexed with fructose 1,6-bisphosphate · the same entry in another collection · chain A against A, TM-score 1.00
- P04075 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P04075) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04075
- Elsewhere: RCSB PDB 4ALD · PDBe 4ALD · UniProt P04075
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