Research workbench
Leishmania major cysteine synthase
Analyse Leishmania major cysteine synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4AIR
- Type
- protein
- Length
- 608 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine synthase
- EC
- 2.5.1.47
- UniProt
- Q4Q159
- Ligands
- FGA, CL
- Pockets
- 7 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine synthase (EC 2.5.1.47) | protein | 304 | 48% helix, 19% strand | Q4Q159 |
| B | Cysteine synthase (EC 2.5.1.47) | protein | 304 | 48% helix, 19% strand | Q4Q159 |
Ligands and binding sites
- FGA · Gamma-D-glutamic acid · ligand · 9 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 170 | 0.68 | 0.88 | 30 | empty |
| 2 | 320 | 0.59 | 0.77 | 42 | FGA, CL |
| 3 | 265 | 0.55 | 0.77 | 38 | FGA |
| 4 | 130 | 0.53 | 0.82 | 24 | empty |
| 5 | 101 | 0.39 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 3367 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 4AIR · Leishmania major cysteine synthase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4Q159
- Elsewhere: RCSB PDB 4AIR · PDBe 4AIR · UniProt Q4Q159
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