Research workbench
Crystal structure of the reactive loop cleaved zpi in I2 space group
Analyse Crystal structure of the reactive loop cleaved zpi in I2 space group in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4AFX
- Type
- protein
- Length
- 381 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein Z dependent protease inhibitor
- UniProt
- Q9UK55
- Ligands
- NA, CA, PO4
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein Z dependent protease inhibitor | protein | 347 | 35% helix, 34% strand | Q9UK55 |
| B | Protein Z dependent protease inhibitor | protein | 34 | 0% helix, 53% strand | Q9UK55 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
- CA · Calcium ion · metal · chains A
- PO4 · Phosphate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.49 | 0.78 | 23 | NA |
| 2 | 109 | 0.47 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2462 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
- 4AFX · Crystal structure of the reactive loop cleaved ZPI in I2 space group · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UK55 · AlphaFold monomer V2.0 prediction for protein Z-dependent protease inhibitor (Q9UK55) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UK55
- Elsewhere: RCSB PDB 4AFX · PDBe 4AFX · UniProt Q9UK55
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