Research workbench
Symmetric dimethylation of H3 arginine 2 is a novel histone mark that supports euchromatin maintenance
Analyse Symmetric dimethylation of H3 arginine 2 is a novel histone mark that supports… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4A7J
- Type
- protein
- Length
- 309 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 5; Histone H3.1T
- UniProt
- P61964, Q16695
- Pockets
- 1 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat-containing protein 5 | protein | 303 | 0% helix, 52% strand | P61964 |
| B | Histone H3.1T | protein | 6 | 0% helix, 0% strand | Q16695 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 513 | 0.73 | 0.81 | 44 | empty |
Interfaces
1 interface between chains.
- A–B · 575 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 4A7J · Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports… · the same entry in another collection · chain A against A, TM-score 1.00
- Q16695 · AlphaFold monomer V2.0 prediction for histone H3.1T (Q16695) · a predicted model of the same protein · chain B against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Every structure of UniProt Q16695
- Elsewhere: RCSB PDB 4A7J · PDBe 4A7J · UniProt P61964 · UniProt Q16695
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