Research workbench
Crystal structure of computationally redesigned gamma- adaptin appendage domain forming a symmetric homodimer
Analyse Crystal structure of computationally redesigned gamma- adaptin appendage domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZY7
- Type
- protein
- Length
- 232 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-1 complex subunit gamma-1
- UniProt
- P22892
- Pockets
- 1 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ap-1 complex subunit gamma-1 | protein | 116 | 5% helix, 55% strand | P22892 |
Ligands and binding sites
- IPA · Isopropyl alcohol · additive · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.76 | 0.99 | 24 | IPA |
Interfaces
1 interface between chains.
- A–B · 745 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 3ZY7 · Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a… · the same entry in another collection · chain A against A, TM-score 1.00
- P22892 · AlphaFold monomer V2.0 prediction for ap-1 complex subunit gamma-1 (P22892) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22892
- Elsewhere: RCSB PDB 3ZY7 · PDBe 3ZY7 · UniProt P22892
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