UniProt P22892
AP-1 complex subunit gamma-1 (P22892)
AP-1 complex subunit gamma-1 (UniProt P22892): 32 experimental structures and 1 predicted model on GenesisL1, 77 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22892
- Protein
- AP-1 complex subunit gamma-1
- Experimental structures
- 32
- Predicted models
- 1
- Pockets
- 77 · 10 records with a druggable one
Structures
33 records of P22892 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GYU | Gamma-adaptin appendage domain from clathrin adaptor AP1 | x-ray diffraction | A | — | — |
| 1GYU | Gamma-adaptin appendage domain from clathrin adaptor AP1 | x-ray diffraction | A | — | — |
| 1GYV | Gamma-adaptin appendage domain from clathrin adaptor AP1, L762E mutant | x-ray diffraction | A | — | — |
| 1GYV | Gamma-adaptin appendage domain from clathrin adaptor AP1, L762E mutant | x-ray diffraction | A | — | — |
| 1GYW | Gamma-adaptin appendage domain from clathrin adaptor AP1 A753D mutant | x-ray diffraction | A, B | — | — |
| 1GYW | Gamma-adaptin appendage domain from clathrin adaptor AP1 A753D mutant | x-ray diffraction | A, B | — | — |
| 1W63 | AP1 clathrin adaptor core | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1W63 | AP1 clathrin adaptor core | x-ray diffraction | A, C, E, G, I, K | — | — |
| 2A7B | On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data… | x-ray diffraction | A | — | — |
| 2A7B | On the routine use of soft X-rays in macromolecular crystallography, part III- the optimal data… | x-ray diffraction | A | — | — |
| 3ZY7 | Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric… | x-ray diffraction | A, B | — | — |
| 3ZY7 | Crystal structure of computationally redesigned gamma- adaptin appendage domain forming a symmetric… | x-ray diffraction | A, B | — | — |
| 4HMY | Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1 | x-ray diffraction | A | — | — |
| 4HMY | Structural basis for recruitment and activation of the ap-1 clathrin adaptor complex by ARF1 | x-ray diffraction | A | — | — |
| 4P6Z | Crystal structure of the human BST2 cytoplasmic domain and the HIV-1 vpu cytoplasmic domain bound… | x-ray diffraction | G | — | — |
| 6CM9 | Structure of the cargo bound AP-1:Arf1:tetherin-Nef closed trimer monomeric subunit | electron microscopy | G | — | 9 (best 0.75) |
| 6CM9 | Structure of the cargo bound ap-1:ARF1:TETHERIN-nef closed trimer monomeric subunit | electron microscopy | G | — | — |
| 6CRI | Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer | electron microscopy | G, Q, R | — | 10 (best 0.74) |
| 6CRI | Structure of the cargo bound ap-1:ARF1:TETHERIN-nef stable closed trimer | electron microscopy | G, Q, R | — | — |
| 6D83 | Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric… | electron microscopy | G | — | 12 (best 0.71) |
| 6D83 | Structure of the cargo bound ap-1:ARF1:TETHERIN-nef (L164A, L165A) dileucine mutant dimer monomeric… | electron microscopy | G | — | — |
| 6D84 | Structure of the cargo bound ap-1:ARF1:TETHERIN-nef (L164A, L165A) dileucine mutant dimer | electron microscopy | G, K | — | — |
| 6DFF | Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer | electron microscopy | G | — | 10 (best 0.72) |
| 6DFF | Structure of the cargo bound ap-1:ARF1:TETHERIN-nef monomer | electron microscopy | G | — | — |
| 7R4H | phospho-STING binding to adaptor protein complex-1 | electron microscopy | G | — | 12 (best 0.79) |
| 8D4D | gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide… | electron microscopy | G, E | — | 6 (best 0.68) |
| 8D4G | gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide… | electron microscopy | G, E | — | 5 (best 0.67) |
| 8D9R | AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide membrane tubes, centered on… | electron microscopy | G, R, T, U, V, W | — | 6 (best 0.72) |
| 8D9S | AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide membrane tubes, centered on beta-Arf1 | electron microscopy | G, R, T, U, V, W | — | 4 (best 0.76) |
| 8D9T | AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes, centered on… | electron microscopy | G, R, T, U, V, W | — | — |
| 8D9U | AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes, centered on… | electron microscopy | G, R, T, U, V, W | — | — |
| 8D9W | beta-Arf1 homodimeric interface within AP-1, Arf1, Nef, MHC-I lattice on narrow tubes | electron microscopy | K, O | — | 3 (best 0.65) |
| P22892 | AlphaFold monomer V2.0 prediction for ap-1 complex subunit gamma-1 (P22892) | predicted | A | — | — |
Experiment against prediction
- 1GYV chain A against the predicted model P22892: TM-score 0.99, RMSD 0.48 Å
- 1GYV chain A against the predicted model P22892: TM-score 0.99, RMSD 0.48 Å
- 1GYU chain A against the predicted model P22892: TM-score 0.99, RMSD 0.50 Å
- 1GYU chain A against the predicted model P22892: TM-score 0.99, RMSD 0.50 Å
- 3ZY7 chain B against the predicted model P22892: TM-score 0.98, RMSD 0.61 Å
- 3ZY7 chain B against the predicted model P22892: TM-score 0.98, RMSD 0.61 Å
- 3ZY7 chain A against the predicted model P22892: TM-score 0.98, RMSD 0.62 Å
- 3ZY7 chain A against the predicted model P22892: TM-score 0.98, RMSD 0.62 Å
- 2A7B chain A against the predicted model P22892: TM-score 0.98, RMSD 0.64 Å
- 2A7B chain A against the predicted model P22892: TM-score 0.98, RMSD 0.64 Å
Elsewhere
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