Research workbench
Crystal structure of POFUT1 in complex with GDP (high resolution dataset)
Analyse Crystal structure of POFUT1 in complex with GDP (high resolution dataset) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZY2
- Type
- protein
- Length
- 342 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative GDP-fucose protein O-fucosyltransferase 1
- EC
- 2.4.1.221
- UniProt
- Q18014
- Ligands
- GDP, MN
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) | protein | 342 | 42% helix, 15% strand | Q18014 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 246 | 0.61 | 0.80 | 35 | MN, GDP |
| 2 | 86 | 0.45 | 0.80 | 16 | empty |
| 3 | 80 | 0.38 | 0.77 | 17 | empty |
| 4 | 75 | 0.37 | 0.77 | 23 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3ZY2 · Crystal structure of POFUT1 in complex with GDP (High resolution dataset) · the same entry in another collection · chain A against A, TM-score 1.00
- Q18014 · AlphaFold monomer V2.0 prediction for GDP-fucose protein O-fucosyltransferase 1 (Q18014) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q18014
- Elsewhere: RCSB PDB 3ZY2 · PDBe 3ZY2 · UniProt Q18014
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