Research workbench
Structure of eukaryotic translation initiation factor EIF3I complex with EIF3B C-terminus (655-700)
Analyse Structure of eukaryotic translation initiation factor EIF3I complex with EIF3B… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZWL
- Type
- protein
- Length
- 769 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation…
- UniProt
- P40217, P06103
- Pockets
- 8 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Eukaryotic translation initiation factor 3 subunit I | protein | 339 | 4% helix, 52% strand | P40217 |
| D | Eukaryotic translation initiation factor 3 subunit I | protein | 352 | 4% helix, 50% strand | P40217 |
| E, F | Eukaryotic translation initiation factor 3 subunit B | protein | 39 | 69% helix, 0% strand | P06103 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 676 | 0.81 | 0.85 | 62 | empty |
| 2 | 1084 | 0.80 | 0.82 | 101 | empty |
| 3 | 167 | 0.44 | 0.75 | 22 | empty |
| 4 | 148 | 0.42 | 0.74 | 20 | empty |
| 5 | 58 | 0.42 | 0.81 | 12 | empty |
Interfaces
3 interfaces between chains.
- D–F · 1098 Ų buried · 7 hydrogen bonds · protein-protein
- B–E · 1096 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 387 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3ZWL · Structure of eukaryotic translation initiation factor eIF3i complex with eIF3b C-terminus… · the same entry in another collection · chain F against F, TM-score 1.00
- P40217 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain B against A, TM-score 0.96
- P06103 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain F against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40217
- Every structure of UniProt P06103
- Elsewhere: RCSB PDB 3ZWL · PDBe 3ZWL · UniProt P40217 · UniProt P06103
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