Research workbench
R-state human carbonmonoxyhemoglobin alpha-A53S
Analyse R-state human carbonmonoxyhemoglobin alpha-A53S in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1AJ9
- Type
- protein
- Length
- 287 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemoglobin (alpha chain); Hemoglobin (beta chain)
- UniProt
- P69905, P68871
- Ligands
- HEM, CMO, PO4
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemoglobin (alpha chain) | protein | 141 | 74% helix, 0% strand | P69905 |
| B | Hemoglobin (beta chain) | protein | 146 | 79% helix, 0% strand | P68871 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
- CMO · Carbon monoxide · ion · 2 copies · chains A, B
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 232 | 0.73 | 0.87 | 28 | HEM, CMO |
| 2 | 202 | 0.68 | 0.85 | 25 | HEM, CMO |
| 3 | 221 | 0.54 | 0.77 | 37 | empty |
| 4 | 55 | 0.28 | 0.74 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 920 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1AJ9 · R-state human carbonmonoxyhemoglobin alpha-A53S · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P69905
- Every structure of UniProt P68871
- Elsewhere: RCSB PDB 1AJ9 · PDBe 1AJ9 · UniProt P69905 · UniProt P68871
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.