Research workbench
Glge isoform 1 from streptomyces coelicolor with maltose bound
Analyse Glge isoform 1 from streptomyces coelicolor with maltose bound in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZT5
- Type
- protein
- Length
- 2,596 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative glucanohydrolase PEP1A
- EC
- 2.4.1.-, 3.2.1.-
- UniProt
- Q9L1K2
- Ligands
- GLC
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Putative glucanohydrolase PEP1A (EC 2.4.1.-, 3.2.1.-) | protein | 649 | 33% helix, 26% strand | Q9L1K2 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1138 | 0.79 | 0.81 | 81 | GLC |
| 2 | 1105 | 0.79 | 0.81 | 81 | GLC |
| 3 | 1081 | 0.78 | 0.80 | 76 | GLC |
| 4 | 801 | 0.77 | 0.81 | 59 | empty |
| 5 | 993 | 0.76 | 0.78 | 107 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2261 Ų buried · 30 hydrogen bonds · protein-protein
- C–D · 2246 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 30 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3ZT5 · GlgE isoform 1 from Streptomyces coelicolor with maltose bound · the same entry in another collection · chain D against D, TM-score 1.00
- Q9L1K2 · AlphaFold monomer V2.0 prediction for alpha-1,4-GLUCAN:MALTOSE-1-phosphate… · a predicted model of the same protein · chain C against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9L1K2
- Elsewhere: RCSB PDB 3ZT5 · PDBe 3ZT5 · UniProt Q9L1K2
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