Research workbench
Structure of E.COLI rhomboid protease glpg in complex with monobactam L62
Analyse Structure of E.COLI rhomboid protease glpg in complex with monobactam L62 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZMH
- Type
- protein
- Length
- 180 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rhomboid protease glpg
- EC
- 3.4.21.105
- UniProt
- P09391
- Ligands
- BNG, L62, 78C, CL
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rhomboid protease glpg (EC 3.4.21.105) | protein | 180 | 76% helix, 0% strand | P09391 |
Ligands and binding sites
- BNG · nonyl beta-D-glucopyranoside · ligand · 6 copies · chains A
- L62 · cyclopentyl N-[(1R)-3-oxidanylidene-1-phenyl-propyl]carbamate · ligand · chains A
- 78C · Cyclopentyl 2-oxo-4-phenylazetidine-1-carboxylate · ligand · chains A
- CL · Chloride ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.69 | 0.89 | 20 | L62 |
| 2 | 65 | 0.33 | 0.76 | 15 | BNG |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 3ZMH · Structure of E.coli rhomboid protease GlpG in complex with monobactam L62 · the same entry in another collection · chain A against A, TM-score 1.00
- P09391 · AlphaFold monomer V2.0 prediction for rhomboid protease glpg (P09391) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09391
- Elsewhere: RCSB PDB 3ZMH · PDBe 3ZMH · UniProt P09391
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