UniProt P09391
Rhomboid protease GlpG (P09391)
Rhomboid protease GlpG (UniProt P09391), EC 3.4.21.105: 49 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09391
- Protein
- Rhomboid protease GlpG
- EC
- 3.4.21.105
- Experimental structures
- 49
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 13 · 2 records with a druggable one
Structures
50 records of P09391 in the MolNFT archive: 49 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IC8 | Crystal structure of GlpG | x-ray diffraction | A | — | — |
| 2IC8 | Crystal structure of glpg | x-ray diffraction | A | — | — |
| 2IRV | Crystal structure of GlpG, a rhomboid intramembrane serine protease | x-ray diffraction | A, B | — | — |
| 2IRV | Crystal structure of glpg, a rhomboid intramembrane serine protease | x-ray diffraction | A, B | — | — |
| 2NRF | Crystal Structure of GlpG, a Rhomboid family intramembrane protease | x-ray diffraction | A, B | — | — |
| 2NRF | Crystal structure of glpg, a rhomboid family intramembrane protease | x-ray diffraction | A, B | — | — |
| 2O7L | The open-cap conformation of GlpG | x-ray diffraction | A | — | — |
| 2O7L | The open-cap conformation of glpg | x-ray diffraction | A | — | — |
| 2XOV | Crystal Structure of E.coli rhomboid protease GlpG, native enzyme | x-ray diffraction | A | — | — |
| 2XOV | Crystal structure of E.COLI rhomboid protease glpg, native enzyme | x-ray diffraction | A | — | — |
| 2XOW | Structure of GlpG in complex with a mechanism-based isocoumarin inhibitor | x-ray diffraction | A | — | — |
| 2XOW | Structure of glpg in complex with a mechanism-based isocoumarin inhibitor | x-ray diffraction | A | — | — |
| 2XTU | Structure of E.coli rhomboid protease GlpG active site mutant, S201T in trigonal crystal form | x-ray diffraction | A | — | — |
| 2XTU | Structure of E.COLI rhomboid protease glpg active site mutant, S201T in trigonal crystal form | x-ray diffraction | A | — | — |
| 2XTV | Structure of E.coli rhomboid protease GlpG, active site mutant, S201T, orthorhombic crystal form | x-ray diffraction | A | — | — |
| 2XTV | Structure of E.COLI rhomboid protease glpg, active site mutant, S201T, orthorhombic crystal form | x-ray diffraction | A | — | — |
| 3B44 | Crystal structure of GlpG W136A mutant | x-ray diffraction | A | — | — |
| 3B44 | Crystal structure of glpg W136A mutant | x-ray diffraction | A | — | — |
| 3B45 | Crystal structure of GlpG at 1.9A resolution | x-ray diffraction | A | — | — |
| 3B45 | Crystal structure of glpg at 1.9A resolution | x-ray diffraction | A | — | — |
| 3TXT | Crystal structure of GlpG in complex with inhibitor DFP | x-ray diffraction | A | — | — |
| 3TXT | Crystal structure of glpg in complex with inhibitor dfp | x-ray diffraction | A | — | — |
| 3UBB | The crystal structure of GlpG in complex with a phosphonofluoridate inhibitor | x-ray diffraction | A | — | — |
| 3UBB | The crystal structure of glpg in complex with a phosphonofluoridate inhibitor | x-ray diffraction | A | — | — |
| 3ZEB | A complex of GlpG with isocoumarin inhibitor covalently bonded to serine 201 and histidine 150 | x-ray diffraction | A | — | — |
| 3ZEB | A complex of glpg with isocoumarin inhibitor covalently bonded to serine 201 and histidine 150 | x-ray diffraction | A | — | — |
| 3ZMH | Structure of E.coli rhomboid protease GlpG in complex with monobactam L62 | x-ray diffraction | A | — | — |
| 3ZMH | Structure of E.COLI rhomboid protease glpg in complex with monobactam L62 | x-ray diffraction | A | — | — |
| 3ZMI | Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 | x-ray diffraction | A | — | — |
| 3ZMI | Structure of E.COLI rhomboid protease glpg in complex with monobactam L29 | x-ray diffraction | A | — | — |
| 3ZMJ | Structure of E.coli rhomboid protease GlpG in complex with monobactam L61 | x-ray diffraction | A | — | — |
| 3ZMJ | Structure of E.COLI rhomboid protease glpg in complex with monobactam L61 | x-ray diffraction | A | — | — |
| 3ZOT | Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 (data set 2) | x-ray diffraction | A | — | — |
| 3ZOT | Structure of E.COLI rhomboid protease glpg in complex with monobactam L29 (data set 2) | x-ray diffraction | A | — | — |
| 4H1D | Cocrystal structure of GlpG and DFP | x-ray diffraction | A | — | — |
| 4H1D | Cocrystal structure of glpg and dfp | x-ray diffraction | A | — | — |
| 4HDD | Domain swapping in the cytoplasmic domain of the Escherichia coli rhomboid protease | x-ray diffraction | A | — | — |
| 4HDD | Domain swapping in the cytoplasmic domain of the escherichia COLI rhomboid protease | x-ray diffraction | A | — | — |
| 4NJN | Crystal Structure of E.coli GlpG at pH 4.5 | x-ray diffraction | A | — | — |
| 4NJN | Crystal structure of E.COLI glpg at pH 4.5 | x-ray diffraction | A | — | — |
| 4NJP | Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity | x-ray diffraction | A | — | — |
| 4NJP | Proteolysis inside the membrane is a rate-governed reaction not driven by substrate affinity | x-ray diffraction | A | — | — |
| 5MT6 | Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-phenylethyl-ketoamide | x-ray diffraction | A | BNG | — |
| 5MT6 | Structure of E.COLI glpg in complex with peptide derived inhibitor ac- rvrha-phenylethyl-ketoamide | x-ray diffraction | A | V9C, BNG | — |
| 5MT7 | Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-VRHA-cmk | x-ray diffraction | A | — | 2 (best 0.38) |
| 5MT7 | Structure of E.COLI glpg in complex with peptide derived inhibitor ac- vrha-cmk | x-ray diffraction | A | 0QE | — |
| 5MT8 | Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-cmk | x-ray diffraction | A | BNG, CL | 3 (best 0.38) |
| 5MT8 | Structure of E.COLI glpg in complex with peptide derived inhibitor ac- rvrha-cmk | x-ray diffraction | A | 0QE, BNG, CL | — |
| 8AB5 | Structure of E. coli GlpG in complex with peptide derived inhibitor… | x-ray diffraction | A, B | — | 5 (best 0.63) |
| P09391 | AlphaFold monomer V2.0 prediction for rhomboid protease glpg (P09391) | predicted | A | — | 3 (best 0.54) |
Ligands
Experiment against prediction
- 3ZMI chain A against the predicted model P09391: TM-score 0.99, RMSD 0.52 Å
- 3ZMI chain A against the predicted model P09391: TM-score 0.99, RMSD 0.52 Å
- 2O7L chain A against the predicted model P09391: TM-score 0.99, RMSD 0.54 Å
- 2O7L chain A against the predicted model P09391: TM-score 0.99, RMSD 0.54 Å
- 5MT7 chain A against the predicted model P09391: TM-score 0.99, RMSD 0.58 Å
- 5MT7 chain A against the predicted model P09391: TM-score 0.99, RMSD 0.58 Å
- 5MT8 chain A against the predicted model P09391: TM-score 0.99, RMSD 0.62 Å
- 5MT8 chain A against the predicted model P09391: TM-score 0.99, RMSD 0.62 Å
- 4H1D chain A against the predicted model P09391: TM-score 0.98, RMSD 0.64 Å
- 4H1D chain A against the predicted model P09391: TM-score 0.98, RMSD 0.64 Å
Elsewhere
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