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Minor-site specific nls (A58)

Analyse Minor-site specific nls (A58) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ZIP
Type: protein
Length: 441 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-2; A58NLS
UniProt: P52293
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-2	protein	426	73% helix, 0% strand	P52293
B	A58NLS	protein	9	44% helix, 0% strand	—
C	A58NLS	protein	6	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.47	0.83	13	empty
2	84	0.37	0.76	13	empty

Interfaces

2 interfaces between chains.

A–B · 670 Å² buried · 13 hydrogen bonds · protein-protein
A–C · 630 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

3ZIP · minor-site specific NLS (A58) · the same entry in another collection · chain A against A, TM-score 1.00
P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 3ZIP · PDBe 3ZIP · UniProt P52293

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