Research workbench
Human MST3 (STK24) in complex with MO25BETA
Analyse Human MST3 (STK24) in complex with MO25BETA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZHP
- Type
- protein
- Length
- 1,166 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium-binding protein 39-like; SERINE/THREONINE-protein kinase 24
- EC
- 2.7.11.1
- UniProt
- Q9H9S4, Q9Y6E0
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 59% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium-binding protein 39-like | protein | 315 | 76% helix, 1% strand | Q9H9S4 |
| B | Calcium-binding protein 39-like | protein | 315 | 77% helix, 1% strand | Q9H9S4 |
| C | SERINE/THREONINE-protein kinase 24 (EC 2.7.11.1) | protein | 272 | 39% helix, 17% strand | Q9Y6E0 |
| D | SERINE/THREONINE-protein kinase 24 (EC 2.7.11.1) | protein | 264 | 40% helix, 17% strand | Q9Y6E0 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains D, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1039 | 0.78 | 0.80 | 117 | empty |
| 2 | 650 | 0.72 | 0.79 | 64 | empty |
| 3 | 809 | 0.70 | 0.76 | 89 | empty |
| 4 | 125 | 0.37 | 0.74 | 21 | empty |
Interfaces
2 interfaces between chains.
- B–C · 944 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 698 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3ZHP · Human MST3 (STK24) in complex with MO25beta · the same entry in another collection · chain D against D, TM-score 1.00
- Q9H9S4 · AlphaFold monomer V2.0 prediction for calcium-binding protein 39-like (Q9H9S4) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9Y6E0 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 24 (Q9Y6E0) · a predicted model of the same protein · chain D against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H9S4
- Every structure of UniProt Q9Y6E0
- Elsewhere: RCSB PDB 3ZHP · PDBe 3ZHP · UniProt Q9H9S4 · UniProt Q9Y6E0
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