UniProt Q9Y6E0
Serine/threonine-protein kinase 24 (Q9Y6E0)
Serine/threonine-protein kinase 24 (UniProt Q9Y6E0), EC 2.7.11.1: 55 experimental structures on GenesisL1, 8 ligands bound, 10 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9Y6E0
- Protein
- Serine/threonine-protein kinase 24
- EC
- 2.7.11.1
- Experimental structures
- 55
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 10 · 2 records with a druggable one
Structures
55 records of Q9Y6E0 in the MolNFT archive: 55 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3CKW | Crystal structure of sterile 20-like kinase 3 (MST3, STK24) | x-ray diffraction | A | — | — |
| 3CKW | Crystal structure of sterile 20-like kinase 3 (MST3, STK24) | x-ray diffraction | A | — | — |
| 3CKX | Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine | x-ray diffraction | A | — | — |
| 3CKX | Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine | x-ray diffraction | A | — | — |
| 3ZHP | Human MST3 (STK24) in complex with MO25beta | x-ray diffraction | C, D | — | — |
| 3ZHP | Human MST3 (STK24) in complex with MO25BETA | x-ray diffraction | C, D | — | — |
| 4O27 | Crystal structure of MST3-MO25 complex with WIF motif | x-ray diffraction | B, C | — | — |
| 4O27 | Crystal structure of MST3-MO25 complex with wif motif | x-ray diffraction | B, C | — | — |
| 4QML | MST3 in complex with AMP-PNP | x-ray diffraction | A | — | — |
| 4QML | MST3 in complex with AMP-pnp | x-ray diffraction | A | — | — |
| 4QMM | MST3 in complex with at-9283, 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-pyrazol-3-yl}-1H-benzimidazo… | x-ray diffraction | A | — | — |
| 4QMM | MST3 in complex with at-9283, 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]… | x-ray diffraction | A | — | — |
| 4QMN | MST3 in complex with BOSUTINIB | x-ray diffraction | A | — | — |
| 4QMN | MST3 in complex with bosutinib | x-ray diffraction | A | — | — |
| 4QMO | MST3 IN COMPLEX WITH Imidazolo-oxindole PKR inhibitor C16 | x-ray diffraction | A | — | — |
| 4QMO | MST3 in complex with imidazolo-oxindole pkr inhibitor C16 | x-ray diffraction | A | — | — |
| 4QMP | MST3 in complex with CDK1/2 inhibitor III, 5-amino-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-difluor… | x-ray diffraction | A | — | — |
| 4QMP | MST3 in complex with CDK1/2 inhibitor III, 5-amino-3-{[4… | x-ray diffraction | A | — | — |
| 4QMQ | MST3 in complex with CP-673451 | x-ray diffraction | A | — | — |
| 4QMQ | MST3 in complex with cp-673451 | x-ray diffraction | A | — | — |
| 4QMS | MST3 in complex with DASATINIB | x-ray diffraction | A | — | — |
| 4QMS | MST3 in complex with dasatinib | x-ray diffraction | A | — | — |
| 4QMT | MST3 in complex with HESPERADIN | x-ray diffraction | A | — | — |
| 4QMT | MST3 in complex with hesperadin | x-ray diffraction | A | — | — |
| 4QMU | MST3 in complex with jnj-7706621, 4-({5-amino-1-[(2,6-DIFLUOROPHENYL)CARBONYL]-1H-1,2,4-triazol-3-YL… | x-ray diffraction | A | — | — |
| 4QMU | MST3 in complex with jnj-7706621, 4-({5-amino-1-[(2,6-difluorophenyl)… | x-ray diffraction | A | — | — |
| 4QMV | MST3 in complex with pf-03814735, N-{2-[(1S,4R)-6-{[4-(cyclobutylamino)-5-(TRIFLUOROMETHYL)PYRIMIDIN… | x-ray diffraction | A | — | — |
| 4QMV | MST3 in complex with pf-03814735, N-{2-[(1S,4R)-6-{[4… | x-ray diffraction | A | — | — |
| 4QMW | MST3 in complex with pp-121, 1-cyclopentyl-3-(1H-PYRROLO[2,3-B]PYRIDIN-5-yl)-1H-PYRAZOLO[3,4-D]PYRIM… | x-ray diffraction | A | — | — |
| 4QMW | MST3 in complex with pp-121, 1-cyclopentyl-3-(1H-PYRROLO[2,3… | x-ray diffraction | A | — | — |
| 4QMX | MST3 in complex with SARACATINIB | x-ray diffraction | A | — | — |
| 4QMX | MST3 in complex with saracatinib | x-ray diffraction | A | — | — |
| 4QMY | MST3 in complex with staurosporine | x-ray diffraction | A | — | — |
| 4QMY | MST3 in complex with staurosporine | x-ray diffraction | A | — | — |
| 4QMZ | MST3 in complex with sunitinib | x-ray diffraction | A | — | — |
| 4QMZ | MST3 in complex with sunitinib | x-ray diffraction | A | — | — |
| 4QO9 | MST3 IN COMPLEX WITH Danusertib | x-ray diffraction | A, B | — | — |
| 4QO9 | MST3 in complex with danusertib | x-ray diffraction | A, B | — | — |
| 4U8Z | Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06447475) | x-ray diffraction | A | — | — |
| 4U8Z | Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (pf- 06447475) | x-ray diffraction | A | — | — |
| 4W8D | Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06454589). | x-ray diffraction | A | — | — |
| 4W8D | Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (pf- 06454589). | x-ray diffraction | A | — | — |
| 4W8E | Structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06645342) | x-ray diffraction | A | — | — |
| 4W8E | Structure of MST3 with a pyrrolopyrimidine inhibitor (pf-06645342) | x-ray diffraction | A | — | — |
| 7B30 | MST3 in complex with compound G-5555 | x-ray diffraction | A | 59T | — |
| 7B31 | MST3 in complex with compound MRIA9 | x-ray diffraction | A | SQ8 | — |
| 7B31 | MST3 in complex with compound MRIA9 | x-ray diffraction | A | SQ8 | — |
| 7B32 | MST3 in complex with MRIA7 | x-ray diffraction | A | SQQ | 3 (best 0.72) |
| 7B32 | MST3 in complex with MRIA7 | x-ray diffraction | A | SQQ | — |
| 7B33 | MST3 in complex with MRIA11 | x-ray diffraction | A | SQE | — |
| 7B34 | MST3 in complex with compound MRIA12 | x-ray diffraction | A | SQK | — |
| 7B35 | MST3 in complex with compound MRIA13 | x-ray diffraction | A, B | SQB | — |
| 8BZI | Human MST3 (STK24) kinase in complex with inhibitor MR39 | x-ray diffraction | A | SJL | — |
| 8BZJ | Human MST3 (STK24) kinase in complex with inhibitor MRLW5 | x-ray diffraction | A, B | SJX | 7 (best 0.68) |
| Q9Y6E0 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 24 (Q9Y6E0) | — | — | — |
Ligands
- SQ8 · 1-[(5-azanyl-1,3-dioxan-2-yl)methyl]-3-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-7-(methylamino)-1,6-naphthyridin-2-one · in 2 records
- SQQ · 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]-2-[(2-methoxyphenyl) amino]pyrido[2,3-d]pyrimidin-7-one · in 2 records
- 59T · 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino) pyrido[2,3-d]pyrimidin-7(8H)-one · in 1 record
- SJL · 8-(4-azanylbutyl)-6-[2,5-bis(fluoranyl)-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one · in 1 record
- SJX · 8-(4-azanylbutyl)-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one · in 1 record
- SQB · 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(3-methoxy-6-methyl-pyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one · in 1 record
- SQE · 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[4-[6-[bis(fluoranyl)methyl]pyridin-2-yl]-2-chloranyl-phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one · in 1 record
- SQK · 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(3-fluoranyl-6-methyl-pyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one · in 1 record
Elsewhere
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