Research workbench
Crystal structure of the kleisin-N smc interface in prokaryotic condensin
Analyse Crystal structure of the kleisin-N smc interface in prokaryotic condensin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZGX
- Type
- protein
- Length
- 830 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromosome partition protein smc; Segregation and condensation protein a
- UniProt
- P51834, P35154
- Pockets
- 10 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromosome partition protein smc | protein | 345 | 47% helix, 18% strand | P51834 |
| B | Chromosome partition protein smc | protein | 351 | 46% helix, 18% strand | P51834 |
| C, Z | Segregation and condensation protein a | protein | 67 | 76% helix, 0% strand | P35154 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 758 | 0.79 | 0.82 | 79 | empty |
| 2 | 1014 | 0.78 | 0.80 | 71 | empty |
| 3 | 397 | 0.73 | 0.83 | 39 | empty |
| 4 | 446 | 0.72 | 0.82 | 43 | empty |
| 5 | 153 | 0.61 | 0.84 | 25 | empty |
Interfaces
6 interfaces between chains.
- B–Z · 1313 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 1302 Ų buried · 16 hydrogen bonds · protein-protein
- C–Z · 1198 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 924 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 325 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3ZGX · Crystal structure of the kleisin-N SMC interface in prokaryotic condensin · the same entry in another collection · chain A against A, TM-score 1.00
- P51834 · AlphaFold monomer V2.0 prediction for chromosome partition protein smc (P51834) · a predicted model of the same protein · chain B against A, TM-score 0.80
- P35154 · AlphaFold monomer V2.0 prediction for segregation and condensation protein a (P35154) · a predicted model of the same protein · chain C against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51834
- Every structure of UniProt P35154
- Elsewhere: RCSB PDB 3ZGX · PDBe 3ZGX · UniProt P51834 · UniProt P35154
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