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Crystal structure of the V58A mutant of human class alpha glutathione transferase in the apo form

Analyse Crystal structure of the V58A mutant of human class alpha glutathione… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ZFL
Type: protein
Length: 414 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione S-transferase A1
EC: 2.5.1.18
UniProt: P08263
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 56% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutathione S-transferase A1 (EC 2.5.1.18)	protein	208	57% helix, 8% strand	P08263
B	Glutathione S-transferase A1 (EC 2.5.1.18)	protein	206	55% helix, 8% strand	P08263

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1068	0.81	0.82	98	empty
2	119	0.40	0.75	19	empty
3	99	0.35	0.74	20	empty
4	84	0.32	0.73	16	empty
5	59	0.31	0.76	11	empty

Interfaces

1 interface between chains.

A–B · 1538 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

3ZFL · Crystal structure of the V58A mutant of human class alpha glutathione transferase in the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08263
Elsewhere: RCSB PDB 3ZFL · PDBe 3ZFL · UniProt P08263

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