UniProt P08263
Glutathione S-transferase A1 (P08263)
Glutathione S-transferase A1 (UniProt P08263), EC 1.11.1.-, 2.5.1.18: 70 experimental structures on GenesisL1, 5 ligands bound, 5 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P08263
- Protein
- Glutathione S-transferase A1
- EC
- 1.11.1.-, 2.5.1.18, 5.3.3.-
- Experimental structures
- 70
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 5 · 1 record with a druggable one
Structures
70 records of P08263 in the MolNFT archive: 70 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GSD | Glutathione transferase A1-1 in unliganded form | x-ray diffraction | A, B, C, D | — | — |
| 1GSD | Glutathione transferase A1-1 in unliganded form | x-ray diffraction | A, B, C, D | — | — |
| 1GSE | Glutathione transferase A1-1 complexed with an ethacrynic acid glutathione conjugate (mutant R15K) | x-ray diffraction | A, B | — | — |
| 1GSE | Glutathione transferase A1-1 complexed with an ethacrynic acid glutathione conjugate (mutant R15K) | x-ray diffraction | A, B | — | — |
| 1GSF | Glutathione transferase A1-1 complexed with ethacrynic acid | x-ray diffraction | A, B, C, D | — | — |
| 1GSF | Glutathione transferase A1-1 complexed with ethacrynic acid | x-ray diffraction | A, B, C, D | — | — |
| 1GUH | Structure determination and refinement of human alpha class glutathione transferase A1-1, and a… | x-ray diffraction | A, B, C, D | — | — |
| 1GUH | Structure determination and refinement of human alpha class glutathione transferase A1-1, and a… | x-ray diffraction | A, B, C, D | — | — |
| 1K3L | Crystal Structure Analysis of S-hexyl-glutathione Complex of Glutathione Transferase at 1.5… | x-ray diffraction | A, B | — | — |
| 1K3L | Crystal structure analysis of S-hexyl-glutathione complex of glutathione transferase at 1.5… | x-ray diffraction | A, B | — | — |
| 1K3O | Crystal Structure Analysis of apo Glutathione S-Transferase | x-ray diffraction | A, B | — | — |
| 1K3O | Crystal structure analysis of apo glutathione S-transferase | x-ray diffraction | A, B | — | — |
| 1K3Y | Crystal Structure Analysis of human Glutathione S-transferase with S-hexyl glutatione and glycerol… | x-ray diffraction | A, B | — | — |
| 1K3Y | Crystal structure analysis of human glutathione S-transferase with S- hexyl glutatione and glycerol… | x-ray diffraction | A, B | — | — |
| 1LBK | Crystal structure of a recombinant glutathione transferase, created by replacing the last seven… | x-ray diffraction | A, B | — | — |
| 1LBK | Crystal structure of a recombinant glutathione transferase, created by replacing the last seven… | x-ray diffraction | A, B | — | — |
| 1PKW | Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione | x-ray diffraction | A, B | — | — |
| 1PKW | Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione | x-ray diffraction | A, B | — | — |
| 1PKZ | Crystal structure of human glutathione transferase (GST) A1-1 | x-ray diffraction | A, B | — | — |
| 1PKZ | Crystal structure of human glutathione transferase (GST) A1-1 | x-ray diffraction | A, B | — | — |
| 1PL1 | Crystal structure of human glutathione transferase (GST) A1-1 in complex with a… | x-ray diffraction | A, B | — | — |
| 1PL1 | Crystal structure of human glutathione transferase (GST) A1-1 in complex with a… | x-ray diffraction | A, B | — | — |
| 1PL2 | Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with… | x-ray diffraction | A, B | — | — |
| 1PL2 | Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with… | x-ray diffraction | A, B | — | — |
| 1USB | Rational design of a novel enzyme - efficient thioester hydrolysis enabled by the incorporation of… | x-ray diffraction | A, B | — | — |
| 1USB | Rational design of a novel enzyme - efficient thioester hydrolysis enabled by the incorporation of… | x-ray diffraction | A, B | — | — |
| 1XWG | Human GST A1-1 T68E mutant | x-ray diffraction | A, B | — | — |
| 1XWG | Human GST A1-1 T68E mutant | x-ray diffraction | A, B | — | — |
| 1YDK | Crystal structure of the I219A mutant of human glutathione transferase A1-1 with S-hexylglutathione | x-ray diffraction | A, B | — | — |
| 1YDK | Crystal structure of the I219A mutant of human glutathione transferase A1-1 with S-hexylglutathione | x-ray diffraction | A, B | — | — |
| 2R3X | Crystal structure of an R15L hGSTA1-1 mutant complexed with S-hexyl-glutathione | x-ray diffraction | A, B | — | — |
| 2R3X | Crystal structure of an R15L HGSTA1-1 mutant complexed with S-hexyl- glutathione | x-ray diffraction | A, B | — | — |
| 2R6K | Crystal structure of an I71V hGSTA1-1 mutant in complex with S-hexylglutathione | x-ray diffraction | A, B | — | — |
| 2R6K | Crystal structure of an I71V HGSTA1-1 mutant in complex with S- hexylglutathione | x-ray diffraction | A, B | — | — |
| 3I69 | Apo Glutathione Transferase A1-1 GIMF-helix mutant | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3I69 | Apo glutathione transferase A1-1 gimf-helix mutant | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3I6A | Human GST A1-1 GIMF mutant with Glutathione | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3I6A | Human GST A1-1 gimf mutant with glutathione | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3IK9 | Human GST A1-1-GIMF with GSDHN | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3IK9 | Human GST A1-1-gimf with gsdhn | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3KTL | Crystal Structure of an I71A human GSTA1-1 mutant in complex with S-hexylglutathione | x-ray diffraction | A, B | — | — |
| 3KTL | Crystal structure of an I71A human GSTA1-1 mutant in complex with S- hexylglutathione | x-ray diffraction | A, B | — | — |
| 3L0H | Crystal Structure Analysis of W21A mutant of human GSTA1-1 in complex with S-hexylglutathione | x-ray diffraction | A, B | — | — |
| 3L0H | Crystal structure analysis of W21A mutant of human GSTA1-1 in complex with S-hexylglutathione | x-ray diffraction | A, B | — | — |
| 3Q74 | Crystal Structure Analysis of the L7A Mutant of the Apo Form of Human Alpha Class Glutathione… | x-ray diffraction | A, B | — | — |
| 3Q74 | Crystal structure analysis of the L7A mutant of the apo form of human alpha class glutathione… | x-ray diffraction | A, B | — | — |
| 3U6V | Crystal Structure Analysis of L23A mutant of human GST A1-1 | x-ray diffraction | A, B | — | — |
| 3U6V | Crystal structure analysis of L23A mutant of human GST A1-1 | x-ray diffraction | A, B | — | — |
| 3ZFB | Crystal structure of the I75A mutant of human class alpha glutathione transferase in the apo form | x-ray diffraction | A, B | — | — |
| 3ZFB | Crystal structure of the I75A mutant of human class alpha glutathione transferase in the apo form | x-ray diffraction | A, B | — | — |
| 3ZFL | Crystal structure of the V58A mutant of human class alpha glutathione transferase in the apo form | x-ray diffraction | A, B | — | — |
| 3ZFL | Crystal structure of the V58A mutant of human class alpha glutathione transferase in the apo form | x-ray diffraction | A, B | — | — |
| 4HJ2 | Crystal Structure Analysis of GSTA1-1 in complex with chlorambucil | x-ray diffraction | A, B | — | — |
| 4HJ2 | Crystal structure analysis of GSTA1-1 in complex with chlorambucil | x-ray diffraction | A, B | — | — |
| 5JCU | Crystal structure of HGSTA1-1 with glutathione adduct of phenethyl isothiocyanate and cystein… | x-ray diffraction | A, B, C, D | — | — |
| 5LCZ | Chimeric GST | x-ray diffraction | A, B | GSH | — |
| 5LCZ | Chimeric GST | x-ray diffraction | A, B | GSH | — |
| 5LD0 | Chimeric GST | x-ray diffraction | A | CL | — |
| 5LD0 | Chimeric GST | x-ray diffraction | A | CL | — |
| 6ATO | Crystal structure of HGSTA1-1 complexed with gsh and mpd in each subunit | x-ray diffraction | A, B | GSH | — |
10 records more on the page itself.
Ligands
- GSH · Glutathione · in 3 records
- 9AI · N-prop-2-en-1-ylthioformamide · in 2 records
- CL · Chloride ion · in 2 records
- TZ8 · (2~{R})-2-azanyl-5-[[(2~{R})-3-(hexylcarbamothioylsulfanyl)-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid · in 2 records
- P9H · (2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid · in 1 record
Experiment against prediction
- 5LCZ chain A against the predicted model P04903: TM-score 0.99, RMSD 0.54 Å
- 5LCZ chain A against the predicted model P04903: TM-score 0.99, RMSD 0.54 Å
- 5LD0 chain A against the predicted model P04903: TM-score 0.99, RMSD 0.57 Å
- 5LD0 chain A against the predicted model P04903: TM-score 0.99, RMSD 0.57 Å
- 5LCZ chain B against the predicted model P04903: TM-score 0.99, RMSD 0.66 Å
- 5LCZ chain B against the predicted model P04903: TM-score 0.99, RMSD 0.66 Å
Elsewhere
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