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Ligand · LZ6

LZ6 · L-gamma-glutamyl-S-(2-{[4-(3-carboxypropyl)phenyl](2-chloroethyl)amino}ethyl)-L-cysteinylglycine

LZ6, L-gamma-glutamyl-S-(2-{[4-(3-carboxypropyl)phenyl](2-chloroethyl)amino}ethyl)-L-cysteinylglycine (C24 H35 Cl N4 O8 S, 575.1 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its…

Component
LZ6
Formula
C24 H35 Cl N4 O8 S
Class
ligand
Structures
6
PDB entries
3

Binding sites

LZ6 in 6 structures; the first of them:

  • 3CSH · Crystal Structure of Glutathione Transferase Pi in complex with the… · LZ6 A212 · binds TYR7, PHE8, PRO9, VAL10, ARG13, VAL35, TRP38, LYS44 and 11 more
  • 3CSI · Crystal Structure of the Glutathione Transferase Pi allelic variant*C, I104V/A113V, in… · LZ6 A212 · binds TYR7, PHE8, PRO9, VAL10, ARG13, THR34, VAL35, TRP38 and 10 more
  • 4HJ2 · Crystal Structure Analysis of GSTA1-1 in complex with chlorambucil · LZ6 A301 · binds TYR9, PHE10, GLY14, ARG15, ARG45, GLN53, GLN54, VAL55 and 12 more
  • 3CSH · Crystal structure of glutathione transferase pi in complex with the… · LZ6 A212 · binds TYR7, PHE8, PRO9, VAL10, ARG13, VAL35, TRP38, LYS44 and 11 more
  • 3CSI · Crystal structure of the glutathione transferase pi allelic VARIANT*C, I104V/A113V, in… · LZ6 A212 · binds TYR7, PHE8, PRO9, VAL10, ARG13, THR34, VAL35, TRP38 and 10 more
  • 4HJ2 · Crystal structure analysis of GSTA1-1 in complex with chlorambucil · LZ6 A301 · binds TYR9, PHE10, GLY14, ARG15, ARG45, GLN53, GLN54, VAL55 and 12 more

Residues it binds most

GLN 16, PRO 16, VAL 16, GLY 16, TYR 16, ARG 16, LEU 16, PHE 16, ASP 16, LYS 12 (residue and the binding sites it lines).

Found with

  • GSH · Glutathione
  • CA · Calcium ion
  • CL · Chloride ion
  • SO4 · Sulfate ion
  • MES · 2-(N-morpholino)-ethanesulfonic acid
  • CO3 · Carbonate ion

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