Research workbench
Glycogen synthase kinase 3 beta complexed with axin peptide and inhibitor 7D
Analyse Glycogen synthase kinase 3 beta complexed with axin peptide and inhibitor 7D in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ZDI
- Type
- protein
- Length
- 366 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycogen synthase kinase-3 beta; Axin-1
- EC
- 2.7.11.26, 2.7.11.1
- UniProt
- P49841, O15169
- Ligands
- UGJ, PO4
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycogen synthase kinase-3 beta (EC 2.7.11.26, 2.7.11.1) | protein | 349 | 35% helix, 20% strand | P49841 |
| B | Axin-1 | protein | 17 | 76% helix, 0% strand | O15169 |
Ligands and binding sites
- UGJ · 3,6-Diamino-4-(2-chlorophenyl)thieno[2,3-b]pyridine-2,5-dicarbonitrile · ligand · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.62 | 0.82 | 30 | UGJ |
| 2 | 126 | 0.40 | 0.75 | 29 | empty |
| 3 | 58 | 0.39 | 0.80 | 20 | empty |
| 4 | 65 | 0.31 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 706 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49841
- Every structure of UniProt O15169
- Elsewhere: RCSB PDB 3ZDI · PDBe 3ZDI · UniProt P49841 · UniProt O15169
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.