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Structure of protein kinase B unphosphorylated

Analyse Structure of protein kinase B unphosphorylated in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1GZO
Type: protein
Length: 271 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rac-beta SERINE/THREONINE protein kinase
EC: 2.7.1.-
UniProt: P31751
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rac-beta SERINE/THREONINE protein kinase (EC 2.7.1.-)	protein	271	32% helix, 17% strand	P31751

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	207	0.63	0.83	29	empty
2	164	0.59	0.82	34	empty
3	127	0.44	0.76	21	empty

Compared structures

1GZO · Structure of protein kinase B unphosphorylated · the same entry in another collection · chain A against A, TM-score 1.00
P31751 · AlphaFold monomer V2.0 prediction for rac-beta SERINE/THREONINE- protein kinase (P31751) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31751
Elsewhere: RCSB PDB 1GZO · PDBe 1GZO · UniProt P31751

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