UniProt P31751
RAC-beta serine/threonine-protein kinase (P31751)
RAC-beta serine/threonine-protein kinase (UniProt P31751), EC 2.7.11.1: 35 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P31751
- Protein
- RAC-beta serine/threonine-protein kinase
- EC
- 2.7.11.1
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 1 record with a druggable one
Structures
36 records of P31751 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GZK | Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation | x-ray diffraction | A | — | — |
| 1GZK | Molecular mechanism for the regulation of protein kinase B/ AKT by hydrophobic motif phosphorylation | x-ray diffraction | A | — | — |
| 1GZN | Structure of PKB kinase domain | x-ray diffraction | A | — | — |
| 1GZN | Structure of pkb kinase domain | x-ray diffraction | A | — | — |
| 1GZO | Structure of protein kinase B unphosphorylated | x-ray diffraction | A | — | — |
| 1GZO | Structure of protein kinase B unphosphorylated | x-ray diffraction | A | — | — |
| 1MRV | crystal structure of an inactive Akt2 kinase domain | x-ray diffraction | A | — | — |
| 1MRV | Crystal structure of an inactive AKT2 kinase domain | x-ray diffraction | A | — | — |
| 1MRY | crystal structure of an inactive akt2 kinase domain | x-ray diffraction | A | — | — |
| 1MRY | Crystal structure of an inactive AKT2 kinase domain | x-ray diffraction | A | — | — |
| 1O6K | Structure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP | x-ray diffraction | A | — | — |
| 1O6K | Structure of activated form of pkb kinase domain S474D with GSK3 peptide and AMP-pnp | x-ray diffraction | A | — | — |
| 1O6L | Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with… | x-ray diffraction | A | — | — |
| 1O6L | Crystal structure of an activated AKT/PROTEIN kinase B (pkb-pif chimera) ternary complex with… | x-ray diffraction | A | — | — |
| 1P6S | Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt) | solution nmr | A | — | — |
| 1P6S | Solution structure of the pleckstrin homology domain of human protein kinase B beta (PKB/AKT) | solution nmr | A | — | — |
| 2JDO | Structure of pkb-beta (AKT2) complexed with isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)… | x-ray diffraction | A | — | — |
| 2JDO | Structure of pkb-beta (AKT2) complexed with isoquinoline-5- sulfonic acid (2-(2-(4-chlorobenzyloxy)… | x-ray diffraction | A | — | — |
| 2JDR | Structure of pkb-beta (AKT2) complexed with the inhibitor a-443654 | x-ray diffraction | A | — | — |
| 2JDR | Structure of pkb-beta (AKT2) complexed with the inhibitor a- 443654 | x-ray diffraction | A | — | — |
| 2UW9 | STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piper… | x-ray diffraction | A | — | — |
| 2UW9 | Structure of pkb-beta (AKT2) complexed with 4-(4-chloro… | x-ray diffraction | A | — | — |
| 2X39 | Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin… | x-ray diffraction | A | — | — |
| 2X39 | Structure of 4-amino-N-(4-chlorobenzyl)-1-(7H-PYRROLO(2,3-D)… | x-ray diffraction | A | — | — |
| 2XH5 | Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to… | x-ray diffraction | A | — | — |
| 2XH5 | Structure of 4-(4-tert-butylbenzyl)-1-(7H-PYRROLO(2,3-D) pyrimidin-4-YL)PIPERIDIN-4-amine bound to… | x-ray diffraction | A | — | — |
| 3D0E | Crystal structure of human Akt2 in complex with GSK690693 | x-ray diffraction | A, B | — | — |
| 3D0E | Crystal structure of human AKT2 in complex with GSK690693 | x-ray diffraction | A, B | — | — |
| 3E87 | Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors | x-ray diffraction | A, B | — | — |
| 3E87 | Crystal structures of the kinase domain of AKT2 in complex with ATP- competitive inhibitors | x-ray diffraction | A, B | — | — |
| 3E88 | Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors | x-ray diffraction | A, B | — | — |
| 3E88 | Crystal structures of the kinase domain of AKT2 in complex with ATP- competitive inhibitors | x-ray diffraction | A, B | — | — |
| 3E8D | Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors | x-ray diffraction | A, B | — | — |
| 3E8D | Crystal structures of the kinase domain of AKT2 in complex with ATP- competitive inhibitors | x-ray diffraction | A, B | — | — |
| 9C1W | Structure of AKT2 with compound 3 | x-ray diffraction | A | XOO | 4 (best 0.80) |
| P31751 | AlphaFold monomer V2.0 prediction for rac-beta SERINE/THREONINE- protein kinase (P31751) | predicted | A | — | — |
Ligands
- XOO · 4-{2-[({4-[(2P)-2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde · in 1 record
Experiment against prediction
- 2X39 chain A against the predicted model P31751: TM-score 0.99, RMSD 0.81 Å
- 2X39 chain A against the predicted model P31751: TM-score 0.99, RMSD 0.81 Å
- 2JDO chain A against the predicted model P31751: TM-score 0.98, RMSD 0.82 Å
- 2JDO chain A against the predicted model P31751: TM-score 0.98, RMSD 0.82 Å
- 2UW9 chain A against the predicted model P31751: TM-score 0.98, RMSD 0.88 Å
- 2UW9 chain A against the predicted model P31751: TM-score 0.98, RMSD 0.88 Å
- 2JDR chain A against the predicted model P31751: TM-score 0.98, RMSD 0.91 Å
- 2JDR chain A against the predicted model P31751: TM-score 0.98, RMSD 0.91 Å
- 1O6K chain A against the predicted model P31751: TM-score 0.98, RMSD 0.90 Å
- 1O6K chain A against the predicted model P31751: TM-score 0.98, RMSD 0.90 Å
Elsewhere
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