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Ligand · L20

L20 · (2S)-1-(1H-indol-3-yl)-3-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine

L20, (2S)-1-(1H-indol-3-yl)-3-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine (C24 H23 N5 O, 397.5 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues…

Component
L20
Formula
C24 H23 N5 O
Class
ligand
Structures
10
PDB entries
5

Binding sites

L20 in 10 structures; the first of them:

  • 2JDR · Structure of pkb-beta (AKT2) complexed with the inhibitor a-443654 · L20 A1480 · binds LEU158, GLY159, PHE163, VAL166, ALA179, LYS181, THR213, MET229 and 11 more
  • 2JDS · Structure of cAMP-dependent protein kinase complexed with A-443654 · L20 A1351 · binds LEU49, GLY50, THR51, GLY52, GLY55, ARG56, VAL57, ALA70 and 15 more
  • 2JDV · Structure of PKA-PKB chimera complexed with A-443654 · L20 A1351 · binds LEU49, GLY50, THR51, PHE54, VAL57, ALA70, LYS72, THR104 and 12 more
  • 2UZU · PKA structures of indazole-pyridine series of AKT inhibitors · L20 E1351 · binds LEU49, GLY50, THR51, PHE54, GLY55, ARG56, VAL57, ALA70 and 13 more
  • 5DGZ · Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors · L20 A401 · binds LEU44, GLY45, PHE49, VAL52, ALA65, LYS67, ILE104, LEU120 and 9 more
  • 2JDR · Structure of pkb-beta (AKT2) complexed with the inhibitor a- 443654 · L20 A1480 · binds LEU158, GLY159, PHE163, VAL166, ALA179, LYS181, THR213, MET229 and 11 more
  • 2JDS · Structure of camp-dependent protein kinase complexed with a- 443654 · L20 A1351 · binds LEU49, GLY50, THR51, GLY52, GLY55, ARG56, VAL57, ALA70 and 15 more
  • 2JDV · Structure of PKA-pkb chimera complexed with a-443654 · L20 A1351 · binds LEU49, GLY50, THR51, PHE54, VAL57, ALA70, LYS72, THR104 and 12 more
  • 2UZU · PKA structures of indazole-pyridine series of AKT inhibitors · L20 E1351 · binds LEU49, GLY50, THR51, PHE54, GLY55, ARG56, VAL57, ALA70 and 13 more
  • 5DGZ · Discovery of 3,5-substituted 6-azaindazoles as potent pan-pim inhibitors · L20 A401 · binds LEU44, GLY45, PHE49, VAL52, ALA65, LYS67, ILE104, LEU120 and 9 more

Residues it binds most

GLU 10, LEU 10, THR 8, VAL 10, GLY 10, PHE 10, ALA 10, ASP 10, LYS 10, MET 8 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion

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