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Crystal structure of human cytoplasmic aspartate aminotransferase
Analyse Crystal structure of human cytoplasmic aspartate aminotransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3WZF
- Type
- protein
- Length
- 412 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aspartate aminotransferase, cytoplasmic
- EC
- 2.6.1.1, 2.6.1.3
- UniProt
- P17174
- Pockets
- 3 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aspartate aminotransferase, cytoplasmic (EC 2.6.1.1, 2.6.1.3) | protein | 412 | 43% helix, 13% strand | P17174 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.54 | 0.79 | 28 | empty |
| 2 | 80 | 0.44 | 0.80 | 18 | empty |
| 3 | 139 | 0.43 | 0.75 | 25 | empty |
Compared structures
- 3WZF · Crystal structure of human cytoplasmic aspartate aminotransferase · the same entry in another collection · chain A against A, TM-score 1.00
- P17174 · AlphaFold monomer V2.0 prediction for aspartate aminotransferase, cytoplasmic (P17174) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17174
- Elsewhere: RCSB PDB 3WZF · PDBe 3WZF · UniProt P17174
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