UniProt P17174
Aspartate aminotransferase, cytoplasmic (P17174)
Aspartate aminotransferase, cytoplasmic (UniProt P17174), EC 2.6.1.1, 2.6.1.3: 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 32 pockets. Binding sites, druggability and experiment against…
- UniProt
- P17174
- Protein
- Aspartate aminotransferase, cytoplasmic
- EC
- 2.6.1.1, 2.6.1.3
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 32 · 3 records with a druggable one
Structures
13 records of P17174 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3II0 | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) | x-ray diffraction | A, B, C, D | — | — |
| 3II0 | Crystal structure of human glutamate oxaloacetate transaminase 1 (GOT1) | x-ray diffraction | A, B, C, D | — | — |
| 3WZF | Crystal structure of human cytoplasmic aspartate aminotransferase | x-ray diffraction | A | — | — |
| 3WZF | Crystal structure of human cytoplasmic aspartate aminotransferase | x-ray diffraction | A | — | — |
| 6DNA | Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) | x-ray diffraction | A, B, C, D, E, F | PLP | 20 (best 0.78) |
| 6DNA | Crystal structure of T110A mutant human glutamate oxaloacetate transaminase 1 (GOT1) | x-ray diffraction | A, B, C, D, E, F | PLP | — |
| 6DNB | Crystal structure of T110A:S256A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) | x-ray diffraction | A | PO4 | 4 (best 0.54) |
| 6DNB | Crystal structure of T110A:S256A mutant human glutamate oxaloacetate transaminase 1 (GOT1) | x-ray diffraction | A | PO4 | — |
| 6DND | Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1) | x-ray diffraction | A, B | PLP | 8 (best 0.75) |
| 6DND | Crystal structure of wild-type (wt) human glutamate oxaloacetate transaminase 1 (GOT1) | x-ray diffraction | A, B | PLP | — |
| 6LIG | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) in complex with AH | x-ray diffraction | A, B | EE6, PLP | — |
| 6LIG | Crystal structure of human glutamate oxaloacetate transaminase 1 (GOT1) in complex with ah | x-ray diffraction | A, B | EE6, PLP | — |
| P17174 | AlphaFold monomer V2.0 prediction for aspartate aminotransferase, cytoplasmic (P17174) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6DND chain A against the predicted model P17174: TM-score 0.99, RMSD 0.80 Å
- 6DND chain A against the predicted model P17174: TM-score 0.99, RMSD 0.80 Å
- 6DND chain B against the predicted model P17174: TM-score 0.99, RMSD 0.84 Å
- 6DND chain B against the predicted model P17174: TM-score 0.99, RMSD 0.84 Å
- 6LIG chain A against the predicted model P17174: TM-score 0.99, RMSD 0.87 Å
- 6LIG chain A against the predicted model P17174: TM-score 0.99, RMSD 0.87 Å
- 6LIG chain B against the predicted model P17174: TM-score 0.98, RMSD 0.93 Å
- 6LIG chain B against the predicted model P17174: TM-score 0.98, RMSD 0.93 Å
- 6DNA chain C against the predicted model P17174: TM-score 0.98, RMSD 0.99 Å
- 6DNA chain C against the predicted model P17174: TM-score 0.98, RMSD 0.99 Å
Elsewhere
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