Research workbench
N288Q-N321Q mutant beta-lactamase derived from chromohalobacter SP.560 (condition-1B)
Analyse N288Q-N321Q mutant beta-lactamase derived from chromohalobacter SP.560… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3WS1
- Type
- protein
- Length
- 1,080 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-lactamase
- EC
- 3.5.2.6
- UniProt
- Q76LX5
- Ligands
- CA, CS
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-lactamase (EC 3.5.2.6) | protein | 360 | 40% helix, 22% strand | Q76LX5 |
| B, C | Beta-lactamase (EC 3.5.2.6) | protein | 360 | 38% helix, 22% strand | Q76LX5 |
Ligands and binding sites
- CA · Calcium ion · metal · 10 copies · chains A, B, C
- CS · Cesium ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1108 | 0.74 | 0.77 | 108 | CA |
| 2 | 774 | 0.71 | 0.77 | 73 | empty |
| 3 | 273 | 0.55 | 0.77 | 38 | empty |
| 4 | 256 | 0.54 | 0.77 | 34 | empty |
| 5 | 50 | 0.29 | 0.76 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 358 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 341 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3WS1 · N288Q-N321Q mutant BETA-LACTAMASE DERIVED FROM CHROMOHALOBACTER SP.560 (Condition-1B) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q76LX5
- Elsewhere: RCSB PDB 3WS1 · PDBe 3WS1 · UniProt Q76LX5
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