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Structure of mouse H-chain modified ferritin
Analyse Structure of mouse H-chain modified ferritin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3WNW
- Type
- protein
- Length
- 2,080 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferritin heavy chain
- EC
- 1.16.3.1
- UniProt
- P09528
- Ligands
- MG, FE, K
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, H, I, K | Ferritin heavy chain (EC 1.16.3.1) | protein | 173 | 72% helix, 0% strand | P09528 |
| F, G, J, L | Ferritin heavy chain (EC 1.16.3.1) | protein | 174 | 72% helix, 0% strand | P09528 |
Ligands and binding sites
- MG · Magnesium ion · metal · 20 copies · chains A, B, C, D, E, F, G, H, I, J, K, L
- FE · Fe (III) ion · metal · 4 copies · chains A, J, B, F, C, E, I, K, H, L
- K · Potassium ion · metal · 2 copies · chains B, C
- GOL · Glycerol · additive · 12 copies · chains A, C, J, D, I, B, E, H, K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.76 | 0.98 | 17 | empty |
| 2 | 53 | 0.73 | 0.99 | 13 | empty |
| 3 | 316 | 0.67 | 0.82 | 41 | MG |
| 4 | 308 | 0.66 | 0.82 | 39 | MG |
| 5 | 318 | 0.66 | 0.81 | 39 | MG |
Interfaces
26 interfaces between chains.
- H–K · 1621 Ų buried · 35 hydrogen bonds · protein-protein
- D–I · 1611 Ų buried · 34 hydrogen bonds · protein-protein
- C–J · 1606 Ų buried · 35 hydrogen bonds · protein-protein
- B–E · 1598 Ų buried · 36 hydrogen bonds · protein-protein
- G–I · 738 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3WNW · Structure of Mouse H-chain modified ferritin · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09528
- Elsewhere: RCSB PDB 3WNW · PDBe 3WNW · UniProt P09528
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