Research workbench
Anthranilate phosphoribosyltransferase in complex with pyrophosphate and magnesium
Analyse Anthranilate phosphoribosyltransferase in complex with pyrophosphate and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1GXB
- Type
- protein
- Length
- 1,364 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase
- EC
- 2.4.2.18
- UniProt
- P50384
- Ligands
- POP, MG
- Pockets
- 7 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 54% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 339 | 54% helix, 14% strand | P50384 |
| B | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 339 | 54% helix, 14% strand | P50384 |
| C | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 341 | 54% helix, 13% strand | P50384 |
| D | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 345 | 54% helix, 14% strand | P50384 |
Ligands and binding sites
- POP · Pyrophosphate 2- · ligand · 4 copies · chains A, B, C, D
- MG · Magnesium ion · metal · 3 copies · chains A, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 646 | 0.76 | 0.82 | 53 | POP |
| 2 | 703 | 0.75 | 0.81 | 53 | MG, POP |
| 3 | 596 | 0.75 | 0.82 | 50 | POP |
| 4 | 691 | 0.75 | 0.81 | 48 | MG, POP |
| 5 | 77 | 0.41 | 0.79 | 20 | empty |
Interfaces
2 interfaces between chains.
- B–C · 142 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 109 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1GXB · Anthranilate phosphoribosyltransferase in complex with pyrophosphate and magnesium · the same entry in another collection · chain D against D, TM-score 1.00
- P50384 · AlphaFold monomer V2.0 prediction for anthranilate phosphoribosyltransferase (P50384) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50384
- Elsewhere: RCSB PDB 1GXB · PDBe 1GXB · UniProt P50384
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.