Research workbench
Xlf-XRCC4 complex
Analyse Xlf-XRCC4 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3W03
- Type
- protein
- Length
- 784 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-homologous end-joining factor 1; DNA repair protein XRCC4
- UniProt
- Q9H9Q4, Q13426
- Pockets
- 13 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 48% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-homologous end-joining factor 1 | protein | 231 | 49% helix, 23% strand | Q9H9Q4 |
| B | Non-homologous end-joining factor 1 | protein | 225 | 51% helix, 24% strand | Q9H9Q4 |
| C, D | DNA repair protein XRCC4 | protein | 164 | 43% helix, 32% strand | Q13426 |
Pockets
13 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.59 | 0.88 | 23 | empty |
| 2 | 58 | 0.47 | 0.85 | 15 | empty |
| 3 | 53 | 0.46 | 0.84 | 15 | empty |
| 4 | 104 | 0.43 | 0.77 | 18 | empty |
| 5 | 80 | 0.41 | 0.79 | 20 | empty |
Interfaces
2 interfaces between chains.
- A–B · 3141 Ų buried · 23 hydrogen bonds · protein-protein
- C–D · 1609 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3W03 · XLF-XRCC4 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H9Q4 · AlphaFold monomer V2.0 prediction for non-homologous end-joining factor 1 (Q9H9Q4) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q13426 · AlphaFold monomer V2.0 prediction for DNA repair protein XRCC4 (Q13426) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H9Q4
- Every structure of UniProt Q13426
- Elsewhere: RCSB PDB 3W03 · PDBe 3W03 · UniProt Q9H9Q4 · UniProt Q13426
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.