UniProt Q9H9Q4
Non-homologous end-joining factor 1 (Q9H9Q4)
Non-homologous end-joining factor 1 (UniProt Q9H9Q4): 30 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 92 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H9Q4
- Protein
- Non-homologous end-joining factor 1
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 92 · 11 records with a druggable one
Structures
31 records of Q9H9Q4 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QM4 | Crystal structure of human XLF/Cernunnos, a non-homologous end-joining factor | x-ray diffraction | A, B, C, D | — | 14 (best 0.74) |
| 2QM4 | Crystal structure of human XLF/CERNUNNOS, a non-homologous end-joining factor | x-ray diffraction | A, B, C, D | — | — |
| 2R9A | Crystal structure of human XLF | x-ray diffraction | A, B | — | 4 (best 0.63) |
| 2R9A | Crystal structure of human xlf | x-ray diffraction | A, B | — | — |
| 3Q4F | Crystal structure of xrcc4/xlf-cernunnos complex | x-ray diffraction | E, F, A, B | — | 18 (best 0.67) |
| 3Q4F | Crystal structure of XRCC4/XLF-cernunnos complex | x-ray diffraction | E, F, A, B | — | — |
| 3RWR | Crystal structure of the human XRCC4-XLF complex | x-ray diffraction | D, E, H, I, L, M, O, Q, S, W, T, X | TBR | 15 (best 0.78) |
| 3RWR | Crystal structure of the human XRCC4-xlf complex | x-ray diffraction | D, E, H, I, L, M, O, Q, S, W, T, X | — | — |
| 3SR2 | Crystal Structure of Human XLF-XRCC4 Complex | x-ray diffraction | C, D, G, H | — | 13 (best 0.79) |
| 3SR2 | Crystal structure of human xlf-XRCC4 complex | x-ray diffraction | C, D, G, H | — | — |
| 3W03 | XLF-XRCC4 complex | x-ray diffraction | A, B | — | 8 (best 0.59) |
| 3W03 | Xlf-XRCC4 complex | x-ray diffraction | A, B | — | — |
| 6ERG | Complex of XLF and heterodimer Ku bound to DNA | x-ray diffraction | C, F | — | 2 (best 0.80) |
| 6ERG | Complex of xlf and heterodimer ku bound to DNA | x-ray diffraction | C, F | — | — |
| 6ERH | Complex of XLF and heterodimer Ku bound to DNA | x-ray diffraction | M, T | — | 2 (best 0.80) |
| 6ERH | Complex of xlf and heterodimer ku bound to DNA | x-ray diffraction | M, T | — | — |
| 7LSY | NHEJ Short-range synaptic complex | electron microscopy | H, I | — | 6 (best 0.77) |
| 7LSY | Nhej short-range synaptic complex | electron microscopy | H, I | — | — |
| 7LT3 | NHEJ Long-range synaptic complex | electron microscopy | H, I | — | — |
| 7LT3 | Nhej long-range synaptic complex | electron microscopy | H, I | — | — |
| 7NFC | Cryo-EM structure of NHEJ super-complex (dimer) | electron microscopy | Q, R | — | 3 (best 0.83) |
| 7NFC | Cryo-EM structure of nhej super-complex (dimer) | electron microscopy | Q, R | — | — |
| 7NFE | Cryo-EM structure of NHEJ super-complex (monomer) | electron microscopy | F, G | — | 2 (best 0.77) |
| 7NFE | Cryo-EM structure of nhej super-complex (monomer) | electron microscopy | F, G | — | — |
| 7ZYG | CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF | electron microscopy | F | — | 2 (best 0.45) |
| 8BHV | DNA-PK XLF mediated dimer bound to PAXX | electron microscopy | Q, R | — | — |
| 8BHY | DNA-PK Ku80 mediated dimer bound to PAXX and XLF | electron microscopy | f, m | — | — |
| 8BOT | Cryo-EM structure of NHEJ supercomplex(trimer) | electron microscopy | Q, R, X, Y | — | — |
| 8EZA | NHEJ Long-range complex with PAXX | electron microscopy | H, I | — | — |
| 8EZB | NHEJ Long-range complex with ATP | electron microscopy | H, I | — | — |
| Q9H9Q4 | AlphaFold monomer V2.0 prediction for non-homologous end-joining factor 1 (Q9H9Q4) | predicted | A | — | 3 (best 0.43) |
Ligands
- TBR · Hexatantalum dodecabromide · in 1 record
Experiment against prediction
- 3Q4F chain E against the predicted model Q9H9Q4: TM-score 0.99, RMSD 0.56 Å
- 3Q4F chain E against the predicted model Q9H9Q4: TM-score 0.99, RMSD 0.56 Å
- 2QM4 chain C against the predicted model Q9H9Q4: TM-score 0.98, RMSD 0.68 Å
- 2QM4 chain C against the predicted model Q9H9Q4: TM-score 0.98, RMSD 0.68 Å
- 2QM4 chain D against the predicted model Q9H9Q4: TM-score 0.98, RMSD 0.67 Å
- 2QM4 chain D against the predicted model Q9H9Q4: TM-score 0.98, RMSD 0.67 Å
- 2R9A chain A against the predicted model Q9H9Q4: TM-score 0.98, RMSD 0.76 Å
- 2R9A chain A against the predicted model Q9H9Q4: TM-score 0.98, RMSD 0.76 Å
- 3W03 chain B against the predicted model Q9H9Q4: TM-score 0.98, RMSD 0.70 Å
- 3W03 chain B against the predicted model Q9H9Q4: TM-score 0.98, RMSD 0.70 Å
Elsewhere
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