MolNFT v1 · #50131 · protein
Crystal structure of human xlf
2R9A · Non-homologous end-joining factor 1: “Crystal structure of human xlf”. X-ray diffraction, 4 pockets (best druggability 0.63). MolNFT v1 #50131 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2R9A
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-homologous end-joining factor 1
- UniProt
- Q9H9Q4
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-homologous end-joining factor 1 | protein | 219 | 48% helix, 26% strand | Q9H9Q4 |
| B | Non-homologous end-joining factor 1 | protein | 214 | 49% helix, 26% strand | Q9H9Q4 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.63 | 0.90 | 26 | empty |
| 2 | 64 | 0.39 | 0.79 | 17 | empty |
| 3 | 83 | 0.37 | 0.76 | 17 | empty |
| 4 | 51 | 0.28 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 3369 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H9Q4
- Elsewhere: RCSB PDB 2R9A · PDBe 2R9A · UniProt Q9H9Q4
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