Research workbench
Crystal structure of REV1-REV7-REV3 ternary complex
Analyse Crystal structure of REV1-REV7-REV3 ternary complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3VU7
- Type
- protein
- Length
- 311 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein REV1; Mitotic spindle assembly checkpoint protein MAD2B; DNA…
- EC
- 2.7.7.-, 2.7.7.7
- UniProt
- Q9UBZ9, Q9UI95, O60673
- Pockets
- 5 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 47% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | DNA repair protein REV1 (EC 2.7.7.-) | protein | 94 | 71% helix, 1% strand | Q9UBZ9 |
| C | Mitotic spindle assembly checkpoint protein MAD2B | protein | 196 | 38% helix, 31% strand | Q9UI95 |
| Z | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) | protein | 21 | 24% helix, 19% strand | O60673 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 219 | 0.50 | 0.75 | 25 | empty |
| 2 | 111 | 0.37 | 0.74 | 21 | empty |
| 3 | 59 | 0.34 | 0.77 | 14 | empty |
| 4 | 50 | 0.30 | 0.77 | 15 | empty |
| 5 | 51 | 0.28 | 0.74 | 14 | empty |
Interfaces
2 interfaces between chains.
- C–Z · 1153 Ų buried · 16 hydrogen bonds · protein-protein
- H–C · 622 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 3VU7 · Crystal structure of REV1-REV7-REV3 ternary complex · the same entry in another collection · chain H against H, TM-score 1.00
- Q9UI95 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain C against A, TM-score 0.98
- Q9UBZ9 · AlphaFold monomer V2.0 prediction for DNA repair protein REV1 (Q9UBZ9) · a predicted model of the same protein · chain H against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBZ9
- Every structure of UniProt Q9UI95
- Every structure of UniProt O60673
- Elsewhere: RCSB PDB 3VU7 · PDBe 3VU7 · UniProt Q9UBZ9 · UniProt Q9UI95 · UniProt O60673
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