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Galectin-8 N-terminal domain in free form

Analyse Galectin-8 N-terminal domain in free form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3VKN
Type: protein
Length: 294 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Galectin-8
UniProt: O00214
Ligands: CL
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Galectin-8	protein	147	2% helix, 55% strand	O00214

Ligands and binding sites

CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	205	0.49	0.75	25	empty

Interfaces

1 interface between chains.

A–B · 294 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

3VKN · Galectin-8 N-terminal domain in free form · the same entry in another collection · chain A against A, TM-score 1.00
O00214 · AlphaFold monomer V2.0 prediction for galectin-8 (O00214) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00214
Elsewhere: RCSB PDB 3VKN · PDBe 3VKN · UniProt O00214

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