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Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from staphylococcus aureus

Analyse Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3VJD
Type: protein
Length: 284 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dehydrosqualene synthase
EC: 2.5.1.-
UniProt: A9JQL9
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dehydrosqualene synthase (EC 2.5.1.-)	protein	284	72% helix, 0% strand	A9JQL9

Ligands and binding sites

TLA · L(+)-tartaric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	526	0.77	0.84	54	TLA
2	60	0.35	0.78	12	empty

Compared structures

3VJD · Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from… · the same entry in another collection · chain A against A, TM-score 1.00
A9JQL9 · AlphaFold monomer V2.0 prediction for 4,4'-diapophytoene synthase (A9JQL9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9JQL9
Elsewhere: RCSB PDB 3VJD · PDBe 3VJD · UniProt A9JQL9

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