Research workbench
Structure of human NOTCH1 transcription complex including csl, ram, ank, and maml-1 on hes-1 promoter DNA sequence
Analyse Structure of human NOTCH1 transcription complex including csl, ram, ank, and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3V79
- Type
- protein + DNA
- Length
- 752 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurogenic locus notch homolog protein 1; Recombining binding protein suppressor of…
- UniProt
- P46531, Q06330, Q92585
- Pockets
- 14 · best druggability 0.80
Structure
x-ray diffraction · 6 distinct chains · 25% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| K | Neurogenic locus notch homolog protein 1 | protein | 218 | 45% helix, 1% strand | P46531 |
| C | Recombining binding protein suppressor of hairless | protein | 424 | 6% helix, 35% strand | Q06330 |
| M | Mastermind-like protein 1 | protein | 55 | 95% helix, 0% strand | Q92585 |
| X | DNA 5'- D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3' | dna | 18 | — | — |
| Y | DNA 5'- D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3' | dna | 18 | — | — |
| R | Ram | protein | 19 | 16% helix, 11% strand | — |
Pockets
14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1095 | 0.80 | 0.82 | 105 | empty |
| 2 | 610 | 0.76 | 0.82 | 63 | empty |
| 3 | 439 | 0.68 | 0.79 | 50 | empty |
| 4 | 103 | 0.68 | 0.91 | 28 | empty |
| 5 | 227 | 0.50 | 0.76 | 33 | empty |
Interfaces
7 interfaces between chains.
- K–C · 1257 Ų buried · 16 hydrogen bonds · protein-protein
- C–M · 1227 Ų buried · 15 hydrogen bonds · protein-protein
- C–R · 973 Ų buried · 11 hydrogen bonds · protein-protein
- X–Y · 762 Ų buried · 61 hydrogen bonds · nucleic-nucleic
- K–M · 650 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3V79 · Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on… · the same entry in another collection · chain R against R, TM-score 1.00
- P46531 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (P46531) · a predicted model of the same protein · chain K against A, TM-score 0.98
- Q06330 · AlphaFold monomer V2.0 prediction for recombining binding protein suppressor of hairless… · a predicted model of the same protein · chain C against A, TM-score 0.96
- Q92585 · AlphaFold monomer V2.0 prediction for mastermind-like protein 1 (Q92585) · a predicted model of the same protein · chain M against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46531
- Every structure of UniProt Q06330
- Every structure of UniProt Q92585
- Elsewhere: RCSB PDB 3V79 · PDBe 3V79 · UniProt P46531 · UniProt Q06330 · UniProt Q92585
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