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Crystal structure of renal tumor suppressor protein, folliculin

Analyse Crystal structure of renal tumor suppressor protein, folliculin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3V42
Type: protein
Length: 395 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Folliculin
UniProt: Q8NFG4
Pockets: 4 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Folliculin	protein	196	51% helix, 15% strand	Q8NFG4
B	Folliculin	protein	199	50% helix, 14% strand	Q8NFG4

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	225	0.49	0.75	42	empty
2	198	0.45	0.74	37	empty
3	149	0.44	0.75	28	empty
4	56	0.30	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 774 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3V42 · Crystal structure of renal tumor suppressor protein, folliculin · the same entry in another collection · chain A against A, TM-score 1.00
Q8NFG4 · AlphaFold monomer V2.0 prediction for folliculin (Q8NFG4) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NFG4
Elsewhere: RCSB PDB 3V42 · PDBe 3V42 · UniProt Q8NFG4

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