Crystal structure of the peptide bound complex of the ankyrin repeat domains of human ANKRA2

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 0% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains A, B
• NA · Sodium ion · metal · 2 copies · chains A
• CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 812 Ų buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 3V31 · Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9H9E1 · AlphaFold monomer V2.0 prediction for ankyrin repeat family a protein 2 (Q9H9E1) · a predicted model of the same protein · chain A against A, TM-score 0.97
• P56524 · AlphaFold monomer V2.0 prediction for histone deacetylase 4 (P56524) · a predicted model of the same protein · chain B against A, TM-score 0.21

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9H9E1
• Every structure of UniProt P56524
• Elsewhere: RCSB PDB 3V31 · PDBe 3V31 · UniProt Q9H9E1 · UniProt P56524