UniProt P56524
Histone deacetylase 4 (P56524)
Histone deacetylase 4 (UniProt P56524), EC 3.5.1.98: 33 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P56524
- Protein
- Histone deacetylase 4
- EC
- 3.5.1.98
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 15 · 2 records with a druggable one
Structures
34 records of P56524 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2H8N | Structure of a glutamine-rich domain from histone deacetylase 4 | x-ray diffraction | A, B, C, D | — | — |
| 2H8N | Structure of a glutamine-rich domain from histone deacetylase 4 | x-ray diffraction | A, B, C, D | — | — |
| 2O94 | The 97H/F mutant Structure of a glutamine-rich domain from histone deacetylase 4 | x-ray diffraction | A, B, C, D | — | — |
| 2O94 | The 97H/F mutant structure of a glutamine-rich domain from histone deacetylase 4 | x-ray diffraction | A, B, C, D | — | — |
| 2VQJ | Structure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor | x-ray diffraction | A | — | — |
| 2VQJ | Structure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor | x-ray diffraction | A | — | — |
| 2VQM | Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor | x-ray diffraction | A | — | — |
| 2VQM | Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor | x-ray diffraction | A | — | — |
| 2VQO | Structure of HDAC4 catalytic domain with a gain-of-function muation bound to a… | x-ray diffraction | A, B | — | — |
| 2VQO | Structure of HDAC4 catalytic domain with a gain-of-function muation bound to a… | x-ray diffraction | A, B | — | — |
| 2VQQ | Structure of HDAC4 catalytic domain (a double cysteine-to-alanine mutant) bound to a… | x-ray diffraction | A, B | — | — |
| 2VQQ | Structure of HDAC4 catalytic domain (a double cysteine-to- alanine mutant) bound to a… | x-ray diffraction | A, B | — | — |
| 2VQV | Structure of HDAC4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid… | x-ray diffraction | A, B | — | — |
| 2VQV | Structure of HDAC4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid… | x-ray diffraction | A, B | — | — |
| 2VQW | Structure of inhibitor-free HDAC4 catalytic domain (with gain-of- function mutation His332Tyr) | x-ray diffraction | G | — | — |
| 2VQW | Structure of inhibitor-free HDAC4 catalytic domain (with gain-of-function mutation HIS332TYR) | x-ray diffraction | G | — | — |
| 3UXG | Crystal structure of RFXANK | x-ray diffraction | B | — | — |
| 3UXG | Crystal structure of rfxank | x-ray diffraction | B | — | — |
| 3UZD | Crystal structure of 14-3-3 GAMMA | x-ray diffraction | B | — | — |
| 3UZD | Crystal structure of 14-3-3 gamma | x-ray diffraction | B | — | — |
| 3V31 | Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2 | x-ray diffraction | B | — | — |
| 3V31 | Crystal structure of the peptide bound complex of the ankyrin repeat domains of human ANKRA2 | x-ray diffraction | B | — | — |
| 4CBT | Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a… | x-ray diffraction | A, B, C | — | — |
| 4CBT | Design, synthesis, and biological evaluation of potent and selective class iia hdac inhibitors as a… | x-ray diffraction | A, B, C | — | — |
| 4CBY | Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a… | x-ray diffraction | A, B, C, D | — | — |
| 4CBY | Design, synthesis, and biological evaluation of potent and selective class iia hdac inhibitors as a… | x-ray diffraction | A, B, C, D | — | — |
| 5A2S | Potent, selective and CNS-penetrant tetrasubstituted cyclopropane class IIa histone deacetylase… | x-ray diffraction | A, B | OTF, ZN, NA | 3 (best 0.78) |
| 5A2S | Potent, selective and cns-penetrant tetrasubstituted cyclopropane class iia histone deacetylase… | x-ray diffraction | A, B | — | — |
| 5ZOO | Crystal structure of histone deacetylase 4 (HDAC4) in complex with a smrt corepressor SP1 fragment | x-ray diffraction | G | K, ZN | — |
| 5ZOP | Crystal structure of histone deacetylase 4 (HDAC4) in complex with a smrt corepressor SP2 fragment | x-ray diffraction | G | K, ZN | — |
| 6FYZ | Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone… | x-ray diffraction | A, B, C | EBE, ZN, NA | 9 (best 0.72) |
| 6FYZ | Development and characterization of a cns-penetrant benzhydryl hydroxamic acid class iia histone… | x-ray diffraction | A, B, C | EBE, ZN, NA | — |
| 7XUZ | Crystal structure of a HDAC4-MEF2A-DNA ternary complex | x-ray diffraction | B, A | — | 3 (best 0.39) |
| P56524 | AlphaFold monomer V2.0 prediction for histone deacetylase 4 (P56524) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 5 records
- NA · Sodium ion · in 3 records
- EBE · (2~{S})-2-(2-fluorophenyl)-2-[4-(2-methylpyrimidin-5-yl)phenyl]-~{N}-oxidanyl-ethanamide · in 2 records
- K · Potassium ion · in 2 records
- OTF · (1S,2S,3S)-1-fluoranyl-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide · in 1 record
Experiment against prediction
- 5ZOO chain G against the predicted model P56524: TM-score 1.00, RMSD 0.44 Å
- 2VQW chain G against the predicted model P56524: TM-score 1.00, RMSD 0.51 Å
- 2VQW chain G against the predicted model P56524: TM-score 1.00, RMSD 0.51 Å
- 4CBT chain B against the predicted model P56524: TM-score 0.99, RMSD 0.58 Å
- 4CBT chain B against the predicted model P56524: TM-score 0.99, RMSD 0.58 Å
- 5ZOP chain G against the predicted model P56524: TM-score 0.99, RMSD 0.69 Å
- 6FYZ chain A against the predicted model P56524: TM-score 0.99, RMSD 0.62 Å
- 6FYZ chain A against the predicted model P56524: TM-score 0.99, RMSD 0.62 Å
- 4CBT chain A against the predicted model P56524: TM-score 0.99, RMSD 0.72 Å
- 4CBT chain A against the predicted model P56524: TM-score 0.99, RMSD 0.72 Å
Elsewhere
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