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The 3-mbt repeat domain of L3MBTL1 in complex with a methyl-lysine mimic

Analyse The 3-mbt repeat domain of L3MBTL1 in complex with a methyl-lysine mimic in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3UWN
Type
protein
Length
318 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
LETHAL(3)MALIGNANT brain tumor-like protein 1
UniProt
Q9Y468
Ligands
UWN, UNX
Pockets
1 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 30% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ALETHAL(3)MALIGNANT brain tumor-like protein 1protein31820% helix, 30% strandQ9Y468

Ligands and binding sites

  • UWN · [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone} · ligand · chains A
  • UNX · Unknown atom or ion · ion · 14 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
17690.720.7860UNX

Compared structures

  • 3UWN · The 3-MBT repeat domain of L3MBTL1 in complex with a methyl-lysine mimic · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9Y468 · AlphaFold monomer V2.0 prediction for LETHAL(3)MALIGNANT brain tumor- like protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.99

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