Research workbench
X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) mutant F247L (F16L)
Analyse X-ray structure of a pentameric ligand gated ion channel from erwinia… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UQ4
- Type
- protein
- Length
- 3,070 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric-acid receptor subunit beta-1
- UniProt
- E0SJQ4
- Ligands
- NA
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Gamma-aminobutyric-acid receptor subunit beta-1 | protein | 307 | 26% helix, 31% strand | E0SJQ4 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B, C, D, E, F, G, H, I, J
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 963 | 0.84 | 0.85 | 105 | empty |
| 2 | 779 | 0.83 | 0.86 | 80 | empty |
| 3 | 784 | 0.83 | 0.86 | 85 | empty |
| 4 | 950 | 0.83 | 0.84 | 95 | empty |
| 5 | 1098 | 0.82 | 0.83 | 112 | empty |
Interfaces
23 interfaces between chains.
- C–D · 2623 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 2604 Ų buried · 26 hydrogen bonds · protein-protein
- G–H · 2600 Ų buried · 24 hydrogen bonds · protein-protein
- H–I · 2594 Ų buried · 26 hydrogen bonds · protein-protein
- F–G · 2590 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 3UQ4 · X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E0SJQ4
- Elsewhere: RCSB PDB 3UQ4 · PDBe 3UQ4 · UniProt E0SJQ4
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