Research workbench
Lysozyme contamination facilitates crystallization of a hetero- TRIMERICCORTACTIN:ARG:LYSOZYME complex
Analyse Lysozyme contamination facilitates crystallization of a hetero… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ULR
- Type
- protein
- Length
- 206 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lysozyme C; Src substrate cortactin; Abelson tyrosine-protein kinase 2
- EC
- 3.2.1.17
- UniProt
- P00698, Q60598, P42684
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 3 distinct chains · 27% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lysozyme C (EC 3.2.1.17) | protein | 129 | 41% helix, 11% strand | P00698 |
| B | Src substrate cortactin | protein | 64 | 5% helix, 42% strand | Q60598 |
| C | Abelson tyrosine-protein kinase 2 | protein | 13 | 0% helix, 0% strand | P42684 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.37 | 0.75 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 527 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 436 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 220 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3ULR · Lysozyme contamination facilitates crystallization of a… · the same entry in another collection · chain A against A, TM-score 1.00
- Q60598 · AlphaFold monomer V2.0 prediction for src substrate cortactin (Q60598) · a predicted model of the same protein · chain B against A, TM-score 0.88
- P42684 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ABL2 (P42684) · a predicted model of the same protein · chain C against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00698
- Every structure of UniProt Q60598
- Every structure of UniProt P42684
- Elsewhere: RCSB PDB 3ULR · PDBe 3ULR · UniProt P00698 · UniProt Q60598 · UniProt P42684
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