UniProt P42684
Abelson tyrosine-protein kinase 2 (P42684)
Abelson tyrosine-protein kinase 2 (UniProt P42684), EC 2.7.10.2: 18 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P42684
- Protein
- Abelson tyrosine-protein kinase 2
- EC
- 2.7.10.2
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 1
Structures
19 records of P42684 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ECD | Solution structure of the human ABL2 SH2 domain | solution nmr | A | — | — |
| 2ECD | Solution structure of the human ABL2 SH2 domain | solution nmr | A | — | — |
| 2KK1 | Solution structure of C-terminal Domain of Tyrosine-protein kinase ABL2 from Homo sapiens… | solution nmr | A | — | — |
| 2KK1 | Solution structure of C-terminal domain of tyrosine-protein kinase ABL2 from homo sapiens… | solution nmr | A | — | — |
| 2XYN | Human ABL2 in complex with aurora kinase inhibitor vx-680 | x-ray diffraction | A, B, C | — | — |
| 2XYN | Human ABL2 in complex with aurora kinase inhibitor vx-680 | x-ray diffraction | A, B, C | — | — |
| 3GVU | The crystal structure of human ABL2 in complex with GLEEVEC | x-ray diffraction | A | — | — |
| 3GVU | The crystal structure of human ABL2 in complex with gleevec | x-ray diffraction | A | — | — |
| 3HMI | The crystal structure of human ABL2 in complex with… | x-ray diffraction | A | — | — |
| 3HMI | The crystal structure of human ABL2 in complex with 5-amino-3-{[4… | x-ray diffraction | A | — | — |
| 3ULR | Lysozyme contamination facilitates crystallization of a hetero-trimericCortactin:Arg:Lysozyme… | x-ray diffraction | C | — | — |
| 3ULR | Lysozyme contamination facilitates crystallization of a hetero- TRIMERICCORTACTIN:ARG:LYSOZYME… | x-ray diffraction | C | — | — |
| 4EIH | Crystal structure of Arg SH2 domain | x-ray diffraction | A | — | — |
| 4EIH | Crystal structure of arg SH2 domain | x-ray diffraction | A | — | — |
| 5NP3 | Abl2 SH3 | x-ray diffraction | A, B, C, D | — | — |
| 5NP3 | ABL2 SH3 | x-ray diffraction | A, B, C, D | — | — |
| 5NP5 | Abl2 SH3 pTyr116/161 | x-ray diffraction | A, B | SO4 | — |
| 5NP5 | ABL2 SH3 PTYR116/161 | x-ray diffraction | A, B | SO4 | — |
| P42684 | AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ABL2 (P42684) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 5NP3 chain B against the predicted model P42684: TM-score 0.97, RMSD 0.53 Å
- 5NP3 chain B against the predicted model P42684: TM-score 0.97, RMSD 0.53 Å
- 2XYN chain A against the predicted model P42684: TM-score 0.96, RMSD 1.27 Å
- 2XYN chain A against the predicted model P42684: TM-score 0.96, RMSD 1.27 Å
- 2XYN chain C against the predicted model P42684: TM-score 0.96, RMSD 1.28 Å
- 2XYN chain C against the predicted model P42684: TM-score 0.96, RMSD 1.28 Å
- 5NP3 chain A against the predicted model P42684: TM-score 0.96, RMSD 0.62 Å
- 5NP3 chain A against the predicted model P42684: TM-score 0.96, RMSD 0.62 Å
- 2XYN chain B against the predicted model P42684: TM-score 0.96, RMSD 1.42 Å
- 2XYN chain B against the predicted model P42684: TM-score 0.96, RMSD 1.42 Å
Elsewhere
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