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Mouse importin alpha: BIMAX2 peptide complex

Analyse Mouse importin alpha: BIMAX2 peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3UKX
Type: protein
Length: 449 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-2; BIMAX2 peptide
UniProt: P52293
Pockets: 2 · best druggability 0.50

Structure

x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Importin subunit alpha-2	protein	426	73% helix, 0% strand	P52293
C	BIMAX2 peptide	protein	23	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	143	0.50	0.79	23	empty
2	93	0.36	0.75	24	empty

Interfaces

1 interface between chains.

B–C · 1747 Å² buried · 49 hydrogen bonds · protein-protein

Compared structures

3UKX · Mouse importin alpha: Bimax2 peptide complex · the same entry in another collection · chain B against B, TM-score 1.00
P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 3UKX · PDBe 3UKX · UniProt P52293

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