Research workbench
Crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine
Analyse Crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UF2
- Type
- protein
- Length
- 1,400 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage colony-stimulating factor 1
- UniProt
- P09603
- Pockets
- 18 · best druggability 0.86
Structure
x-ray diffraction · 9 distinct chains · 57% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, I | Macrophage colony-stimulating factor 1 | protein | 140 | 56% helix, 9% strand | P09603 |
| B | Macrophage colony-stimulating factor 1 | protein | 139 | 57% helix, 9% strand | P09603 |
| C | Macrophage colony-stimulating factor 1 | protein | 143 | 55% helix, 8% strand | P09603 |
| D | Macrophage colony-stimulating factor 1 | protein | 136 | 55% helix, 9% strand | P09603 |
| E | Macrophage colony-stimulating factor 1 | protein | 143 | 55% helix, 8% strand | P09603 |
| F | Macrophage colony-stimulating factor 1 | protein | 138 | 59% helix, 9% strand | P09603 |
| G | Macrophage colony-stimulating factor 1 | protein | 144 | 56% helix, 8% strand | P09603 |
| H | Macrophage colony-stimulating factor 1 | protein | 138 | 61% helix, 9% strand | P09603 |
| J | Macrophage colony-stimulating factor 1 | protein | 139 | 56% helix, 9% strand | P09603 |
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1151 | 0.86 | 0.87 | 125 | empty |
| 2 | 902 | 0.82 | 0.84 | 105 | empty |
| 3 | 226 | 0.77 | 0.91 | 34 | empty |
| 4 | 140 | 0.72 | 0.91 | 27 | empty |
| 5 | 57 | 0.71 | 0.98 | 15 | empty |
Interfaces
23 interfaces between chains.
- E–F · 949 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 935 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 927 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 904 Ų buried · 12 hydrogen bonds · protein-protein
- I–J · 892 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 35 disulfide (disulfide).
Compared structures
- 3UF2 · Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine · the same entry in another collection · chain J against J, TM-score 1.00
- P09603 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 (P09603) · a predicted model of the same protein · chain F against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09603
- Elsewhere: RCSB PDB 3UF2 · PDBe 3UF2 · UniProt P09603
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