UniProt P09603
Macrophage colony-stimulating factor 1 (P09603)
Macrophage colony-stimulating factor 1 (UniProt P09603): 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09603
- Protein
- Macrophage colony-stimulating factor 1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 70 · 6 records with a druggable one
Structures
17 records of P09603 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HMC | Three-dimensional structure of dimeric human recombinant macrophage colony stimulating factor | x-ray diffraction | A, B | — | — |
| 1HMC | Three-dimensional structure of dimeric human recombinant macrophage colony stimulating factor | x-ray diffraction | A, B | — | — |
| 3UEZ | Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine in complex with the… | x-ray diffraction | E, F, G, H | — | 14 (best 0.69) |
| 3UEZ | Crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine in complex with the… | x-ray diffraction | E, F, G, H | — | — |
| 3UF2 | Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | 18 (best 0.86) |
| 3UF2 | Crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4ADF | CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (hCSF-1) CYTOKINE IN COMPLEX WITH THE… | x-ray diffraction | G, H, I, J, K, L, S, T, U, V, W, X | — | 20 (best 0.82) |
| 4ADF | Crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine in complex with the… | x-ray diffraction | G, H, I, J, K, L, S, T, U, V, W, X | — | — |
| 4FA8 | Multi-pronged modulation of cytokine signaling | x-ray diffraction | E, F, G | NAG | 8 (best 0.62) |
| 4FA8 | Multi-pronged modulation of cytokine signaling | x-ray diffraction | E, F, G | — | — |
| 4WRL | Structure of the human CSF-1:CSF-1R complex | x-ray diffraction | B, D | — | 6 (best 0.73) |
| 4WRL | Structure of the human csf-1:CSF-1R complex | x-ray diffraction | B, D | — | — |
| 4WRM | Structure of the human CSF-1:CSF-1R complex | x-ray diffraction | B | — | 2 (best 0.73) |
| 4WRM | Structure of the human csf-1:CSF-1R complex | x-ray diffraction | B | — | — |
| 5LXF | Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant | x-ray diffraction | A, B | — | 2 (best 0.50) |
| 5LXF | Crystal structure of the human macrophage colony stimulating factor M- CSF_C31S variant | x-ray diffraction | A, B | — | — |
| P09603 | AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 (P09603) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
Experiment against prediction
- 3UF2 chain F against the predicted model P09603: TM-score 0.99, RMSD 0.41 Å
- 3UF2 chain F against the predicted model P09603: TM-score 0.99, RMSD 0.41 Å
- 3UF2 chain D against the predicted model P09603: TM-score 0.99, RMSD 0.48 Å
- 3UF2 chain D against the predicted model P09603: TM-score 0.99, RMSD 0.48 Å
- 1HMC chain B against the predicted model P09603: TM-score 0.99, RMSD 0.52 Å
- 1HMC chain B against the predicted model P09603: TM-score 0.99, RMSD 0.52 Å
- 3UF2 chain J against the predicted model P09603: TM-score 0.99, RMSD 0.69 Å
- 3UF2 chain J against the predicted model P09603: TM-score 0.99, RMSD 0.69 Å
- 3UF2 chain E against the predicted model P09603: TM-score 0.98, RMSD 0.70 Å
- 3UF2 chain E against the predicted model P09603: TM-score 0.98, RMSD 0.70 Å
Elsewhere
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