MolNFT v1 · #126261 · protein
Crystal structure of the human macrophage colony stimulating factor M- CSF_C31S variant
5LXF · Macrophage colony-stimulating factor 1: “Crystal structure of the human macrophage colony stimulating factor M- CSF_C31S variant”. X-ray diffraction, 2 pockets (best druggability 0.50). MolNFT v1 #126261 on GenesisL1: 3D structure…
- PDB
- 5LXF
- Type
- protein
- Length
- 295 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage colony-stimulating factor 1
- UniProt
- P09603
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage colony-stimulating factor 1 | protein | 146 | 59% helix, 9% strand | P09603 |
| B | Macrophage colony-stimulating factor 1 | protein | 149 | 56% helix, 10% strand | P09603 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.50 | 0.79 | 28 | empty |
| 2 | 79 | 0.35 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 898 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 5LXF · Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant · the same entry in another collection · chain A against A, TM-score 1.00
- P09603 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 (P09603) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09603
- Elsewhere: RCSB PDB 5LXF · PDBe 5LXF · UniProt P09603
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