Research workbench
Crystal structure of the immunoreceptor tigit igv domain
Analyse Crystal structure of the immunoreceptor tigit igv domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UCR
- Type
- protein
- Length
- 426 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T cell immunoreceptor with ig and itim domains
- UniProt
- Q495A1
- Ligands
- CL
- Pockets
- 3 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | T cell immunoreceptor with ig and itim domains | protein | 106 | 8% helix, 60% strand | Q495A1 |
| C | T cell immunoreceptor with ig and itim domains | protein | 108 | 3% helix, 59% strand | Q495A1 |
Ligands and binding sites
- CL · Chloride ion · ion · 8 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.42 | 0.77 | 23 | empty |
| 2 | 138 | 0.41 | 0.75 | 24 | CL |
| 3 | 52 | 0.26 | 0.74 | 12 | empty |
Interfaces
3 interfaces between chains.
- B–D · 624 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 614 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 483 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3UCR · Crystal structure of the immunoreceptor TIGIT IgV domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q495A1 · AlphaFold monomer V2.0 prediction for T-cell immunoreceptor with ig and itim domains… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q495A1
- Elsewhere: RCSB PDB 3UCR · PDBe 3UCR · UniProt Q495A1
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