UniProt Q495A1
T-cell immunoreceptor with Ig and ITIM domains (Q495A1)
T-cell immunoreceptor with Ig and ITIM domains (UniProt Q495A1): 16 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q495A1
- Protein
- T-cell immunoreceptor with Ig and ITIM domains
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 35 · 4 records with a druggable one
Structures
17 records of Q495A1 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3Q0H | Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) | x-ray diffraction | A, B | — | — |
| 3Q0H | Structure of T-cell immunoreceptor with immunoglobulin and itim domains (tigit) | x-ray diffraction | A, B | — | — |
| 3RQ3 | Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal… | x-ray diffraction | A, B | — | — |
| 3RQ3 | Structure of T-cell immunoreceptor with immunoglobulin and itim domains (tigit) in hexagonal… | x-ray diffraction | A, B | — | — |
| 3UCR | Crystal structure of the immunoreceptor TIGIT IgV domain | x-ray diffraction | A, B, C, D | — | — |
| 3UCR | Crystal structure of the immunoreceptor tigit igv domain | x-ray diffraction | A, B, C, D | — | — |
| 3UDW | Crystal structure of the immunoreceptor TIGIT in complex with Poliovirus receptor… | x-ray diffraction | A, B | — | — |
| 3UDW | Crystal structure of the immunoreceptor tigit in complex with poliovirus receptor… | x-ray diffraction | A, B | — | — |
| 5V52 | Structure of TIGIT bound to nectin-2 (CD112) | x-ray diffraction | A, B | SO4 | 3 (best 0.40) |
| 5V52 | Structure of tigit bound to nectin-2 (CD112) | x-ray diffraction | A, B | SO4 | — |
| 7VYT | Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody… | x-ray diffraction | A, T | — | 7 (best 0.70) |
| 7VYT | Crystal structure of human TIGIT(23-129) in complex with the scfv fragment of anti-tigit antibody… | x-ray diffraction | A, T | — | — |
| 8JEL | Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I | x-ray diffraction | J, E, H, L | — | 6 (best 0.70) |
| 8JEN | Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II | x-ray diffraction | I, J, M, P | — | 3 (best 0.48) |
| 8JEO | Crystal structure of TIGIT in complexed with Tiragolumab | x-ray diffraction | A, D | — | 3 (best 0.70) |
| 8SZY | Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT | x-ray diffraction | T, U | NAG | 13 (best 0.68) |
| Q495A1 | AlphaFold monomer V2.0 prediction for T-cell immunoreceptor with ig and itim domains (Q495A1) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3UDW chain B against the predicted model Q495A1: TM-score 0.98, RMSD 0.53 Å
- 3UDW chain B against the predicted model Q495A1: TM-score 0.98, RMSD 0.53 Å
- 5V52 chain B against the predicted model Q495A1: TM-score 0.98, RMSD 0.56 Å
- 5V52 chain B against the predicted model Q495A1: TM-score 0.98, RMSD 0.56 Å
- 3UCR chain A against the predicted model Q495A1: TM-score 0.98, RMSD 0.77 Å
- 3UCR chain A against the predicted model Q495A1: TM-score 0.98, RMSD 0.77 Å
- 5V52 chain A against the predicted model Q495A1: TM-score 0.98, RMSD 0.56 Å
- 5V52 chain A against the predicted model Q495A1: TM-score 0.98, RMSD 0.56 Å
- 8JEN chain I against the predicted model Q495A1: TM-score 0.97, RMSD 0.85 Å
- 3RQ3 chain A against the predicted model Q495A1: TM-score 0.97, RMSD 0.85 Å
Elsewhere
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