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Human merlin ferm domain

Analyse Human merlin ferm domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3U8Z
Type: protein
Length: 1,023 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Merlin
UniProt: P35240
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 3 distinct chains · 36% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Merlin	protein	260	37% helix, 28% strand	P35240
C	Merlin	protein	266	37% helix, 27% strand	P35240
D	Merlin	protein	237	35% helix, 30% strand	P35240

Pockets

20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1171	0.80	0.81	88	empty
2	363	0.68	0.81	41	empty
3	210	0.66	0.84	25	empty
4	295	0.65	0.81	31	empty
5	325	0.60	0.77	30	empty

Interfaces

3 interfaces between chains.

A–C · 2922 Å² buried · 35 hydrogen bonds · protein-protein
B–D · 1757 Å² buried · 22 hydrogen bonds · protein-protein
A–B · 1038 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

3U8Z · human merlin FERM domain · the same entry in another collection · chain A against A, TM-score 1.00
P35240 · AlphaFold monomer V2.0 prediction for merlin (P35240) · a predicted model of the same protein · chain D against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35240
Elsewhere: RCSB PDB 3U8Z · PDBe 3U8Z · UniProt P35240

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